The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications

Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil
The London School of Hygiene and Tropical Medicine. London, UK
University of California at Los Angeles. David Geffen School of Medicine. Department of Microbiology, Immunology & Molecular Genetics. Los Angeles, USA
Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle. Paris, France
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil
Universidade de São Paulo. Instituto de Biociências. Departamento de Parasitologia. São Paulo, SP, Brasil
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular “Dr. Héctor N. Torres”. Laboratorio de Biología Molecular de la Enfermedad de Chagas. Buenos Aires, Argentina
The London School of Hygiene and Tropical Medicine. London, UK
Universidade Federal do Triângulo Mineiro. Departamento de Ciências Biológicas. Uberaba, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of California at Los Angeles. David Geffen School of Medicine. Department of Microbiology, Immunology & Molecular Genetics. Los Angeles, USA

Resumo em Inglês

The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs.

Palavras-chave

Estirpes de Trypanosoma cruzi
Unidade de digitação discreta
Genotipagem
Filogeografia
Hibridização
Patologia

Palavras-chave em inglês

Trypanosoma cruzi strains
Genotyping
Phylogeography
Hybridization
Pathology

Editor

Elsevier

Referência

ZINGALES, B. S. et al. The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infection, Genetics and Evolution, v. 12, p. 240–253, 2012.

DOI

10.1016/j.meegid.2011.12.009

ISSN

1567-1348

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/15331

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Direito Autoral

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