| Author | Zingales, Bianca Silvana | |
| Author | Miles, Michael A | |
| Author | Campbell, David A | |
| Author | Tibayrenc, Michel | |
| Author | Macedo, Andrea Mara | |
| Author | Teixeira, Marta Maria Geraldes | |
| Author | Schijman, Alejandro G | |
| Author | Llewellyn, Martin S | |
| Author | Silva, Eliane Lages | |
| Author | Machado, Carlos Renato | |
| Author | Andrade, Sonia Gumes | |
| Author | Sturm, Nancy R | |
| Access date | 2016-08-23T12:55:42Z | |
| Available date | 2016-08-23T12:55:42Z | |
| Document date | 2012 | |
| Citation | ZINGALES, B. S. et al. The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. Infection, Genetics and Evolution, v. 12, p. 240–253, 2012. | pt_BR |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15331 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Estirpes de Trypanosoma cruzi | |
| Subject in Portuguese | Unidade de digitação discreta | |
| Subject in Portuguese | Genotipagem | |
| Subject in Portuguese | Filogeografia | |
| Subject in Portuguese | Hibridização | |
| Subject in Portuguese | Patologia | |
| Title | The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.meegid.2011.12.009 | |
| Abstract | The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil | pt_BR |
| Affilliation | The London School of Hygiene and Tropical Medicine. London, UK | pt_BR |
| Affilliation | University of California at Los Angeles. David Geffen School of Medicine. Department of Microbiology, Immunology & Molecular Genetics. Los Angeles, USA | pt_BR |
| Affilliation | Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle. Paris, France | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Biociências. Departamento de Parasitologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto de Investigaciones en Ingeniería Genética y Biología Molecular “Dr. Héctor N. Torres”. Laboratorio de Biología Molecular de la Enfermedad de Chagas. Buenos Aires, Argentina | pt_BR |
| Affilliation | The London School of Hygiene and Tropical Medicine. London, UK | pt_BR |
| Affilliation | Universidade Federal do Triângulo Mineiro. Departamento de Ciências Biológicas. Uberaba, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of California at Los Angeles. David Geffen School of Medicine. Department of Microbiology, Immunology & Molecular Genetics. Los Angeles, USA | pt_BR |
| Subject | Trypanosoma cruzi strains | |
| Subject | Genotyping | |
| Subject | Phylogeography | |
| Subject | Hybridization | |
| Subject | Pathology | |
| Recomended age | Discrete typing unit | |
