Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15897
Full metadata record
DC FieldValue
dc.contributor.authorSilva, Rosiane V. da
dc.contributor.authorMalvezi, Aparecida D.
dc.contributor.authorAugusto, Leonardo da Silva
dc.contributor.authorKian, Danielle
dc.contributor.authorTatakihara, Vera Lucia H.
dc.contributor.authorYamauchi, Lucy M.
dc.contributor.authorYamada-Ogatta, Sueli F.
dc.contributor.authorRizzo, Luiz V.
dc.contributor.authorSchenkman, Sergio
dc.contributor.authorPinge-Filho, Phileno
dc.date.accessioned2016-09-21T18:58:14Z
dc.date.available2016-09-21T18:58:14Z
dc.date.issued2013
dc.identifier.citationSILVA, Rosiane V. da et al. Oral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi. PLoS ONE, v. 8, n. 7, p.1-9, 2013.
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/15897
dc.description.sponsorshipFAPESP, CNPq, Fundação Araucária
dc.language.isopor
dc.publisherKerry Kroffe
dc.rightsopen access
dc.titleOral exposure to Phytomonas serpens attenuates thrombocytopenia and leukopenia during acute infection with Trypanosoma cruzi
dc.typeArticle
dc.identifier.doi10.1371/journal.pone.0068299
dc.description.abstractenMice infected with Trypanosoma cruzi, the agent of Chagas disease, rapidly develop anemia and thrombocytopenia. These effects are partially promoted by the parasite trans-sialidase (TS), which is shed in the blood and depletes sialic acid from the platelets, inducing accelerated platelet clearance and causing thrombocytopenia during the acute phase of disease. Here, we demonstrate that oral immunization of C57BL/6 mice with Phytomonas serpens, a phytoflagellate parasite that shares common antigens with T. cruzi but has no TS activity, reduces parasite burden and prevents thrombocytopenia and leukopenia. Immunization also reduces platelet loss after intraperitoneal injection of TS. In addition, passive transfer of immune sera raised in mice against P. serpens prevented platelet clearance. Thus, oral exposure to P. serpens attenuates the progression of thrombocytopenia induced by TS from T. cruzi. These findings are not only important for the understanding of the pathogenesis of T. cruzi infection but also for developing novel approaches of intervention in Chagas disease.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Microbiologia. Londrina, PR, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Microbiologia. Londrina, PR, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Microbiologia. Londrina, PR, Brasil.
dc.creator.affilliationInstituto Israelita de Ensino e Pesquisa Albert Einstein. São Paulo, SP, Brasil.
dc.creator.affilliationUniversidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.
dc.creator.affilliationUniversidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunopatologia Experimental. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas disease
dc.subject.enparasite trans-sialidase
dc.subject.enKinetoplastida pathogens
dc.subject.decsDoença de Chagas
dc.subject.decsParasitos
dc.subject.decsInterações Hospedeiro-Patógeno
dc.subject.decsTrombocitopenia
dc.subject.decsLeucopenia
Appears in Collections:PR - ICC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Oral exposure to Phytomonas serpens.pdf829.45 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.