Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15912
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dc.contributor.authorSilva, Christiane França
dc.contributor.authorDaliry, Anissa
dc.contributor.authorSilva, Patrícia Bernardino da
dc.contributor.authorAkay, Senol
dc.contributor.authorBanerjee, Moloy
dc.contributor.authorFarahat, Abdelbasset A.
dc.contributor.authorFisher, Mary K.
dc.contributor.authorHu, Laixing
dc.contributor.authorKumar, Arvind
dc.contributor.authorLiu, Zongying
dc.contributor.authorStephens, Chad E.
dc.contributor.authorBoykin, David W.
dc.contributor.authorSoeiro, Maria de Nazaré Correia
dc.date.accessioned2016-09-22T14:53:06Z
dc.date.available2016-09-22T14:53:06Z
dc.date.issued2011
dc.identifier.citationSILVA, Christiane França da; et al. The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro. Parasitology, v.138, n.14, p.1863-1869, Dec. 2011.
dc.identifier.issn0031-1820
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/15912
dc.language.isoeng
dc.publisherCambridge University Press
dc.rightsrestricted access
dc.subject.otherTrypanosoma cruzi
dc.subject.otherDoença de Chagas
dc.subject.otherQuimioterapia
dc.subject.otherarylimidamides
dc.titleThe efficacy of novel arylimidamides against Trypanosoma cruzi in vitro
dc.typeArticle
dc.identifier.doi10.1017/S0031182011001429
dc.description.abstractenThe present study aimed to determine the in vitro biological efficacy and selectivity of 7 novel AIAs upon bloodstream trypomastigotes and intracellular amastigotes of Trypanosoma cruzi. The biological activity of these aromatic compounds was assayed for 48 and 24 h against intracellular parasites and bloodstream forms of T. cruzi (Y strain), respectively. Additional assays were also performed to determine their potential use in blood banks by treating the bloodstream parasites with the compounds diluted in mouse blood for 24 h at 4 °C. Toxicity against mammalian cells was evaluated using primary cultures of cardiac cells incubated for 24 and 48 h with the AIAs and then cellular death rates were determined by MTT colorimetric assays. Our data demonstrated the outstanding trypanocidal effect of AIAs against T. cruzi, especially DB1853, DB1862, DB1867 and DB1868, giving IC50 values ranging between 16 and 70 nanomolar against both parasite forms. All AIAs presented superior efficacy to benznidazole and some, such as DB1868, also demonstrated promising activity as a candidate agent for blood prophylaxis. The excellent anti-trypanosomal efficacy of these novel AIAs against T. cruzi stimulates furtherin vivo studies and justifies the screening of new analogues with the goal of establishing a useful alternative therapy for Chagas disease.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry and Physics. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry and Physics. Georgia, USA.
dc.creator.affilliationAugusta State University. Department of Chemistry. Georgia, USA.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas Disease
dc.subject.enChemotherapy
dc.subject.enarylimidamides
dc.identifier.eissn1469-8161
Appears in Collections:IOC - Artigos de Periódicos

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