Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15955
Full metadata record
DC FieldValue
dc.contributor.authorSoeiro, Maria de Nazaré C.
dc.contributor.authorCastro, Solange Lisboa de
dc.date.accessioned2016-09-27T11:29:40Z
dc.date.available2016-09-27T11:29:40Z
dc.date.issued2011
dc.identifier.citationSOEIRO, Maria de Nazaré C.; CASTRO, Solange Lisboa de. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Medicinal Chemistry Journal, v.5, p.21-30, 2011.
dc.identifier.issn1874-1045
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/15955
dc.language.isoeng
dc.publisherBentham Open
dc.rightsopen access
dc.subject.otherTrypanosoma cruzi
dc.subject.otherDoença de Chagas
dc.subject.otherQuimioterapia experimental
dc.subject.otherNaftoquinonas
dc.subject.otherDiamidinas aromáticos
dc.subject.otherDerivados megazol
dc.titleScreening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
dc.typeArticle
dc.description.abstractenChagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos Chagas (1909), although it still represents an important public health problem in these affected areas, the existing chemotherapy, based on benznidazole and nifurtimox (both introduced more than four decades ago), is far from being considered ideal due to substantial toxicity, variable effect on different parasite stocks and well-known poor activity on the chronic phase. CD is considered one of the major “neglected” diseases of the world, as commercial incentives are very limited to guarantee investments for developing and discovering novel drugs. In this context, our group has been pursuing, over the last years, the efficacy, selectivity, toxicity, cellular targets and mechanisms of action of new potential anti-T. cruzi candidates screened from an in-house compound library of different research groups in the area of medicinal chemistry. A brief review regarding these studies will be discussed, mainly related to the effect on T. cruzi of (i) diamidines and related compounds, (ii) natural naphthoquinone derivatives, and (iii) megazol derivatives.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enexperimental chemotherapy
dc.subject.enaromatic diamidines
dc.subject.ennaphthoquinones
dc.subject.enmegazol derivatives
dc.subject.enChagas Disease
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
marianazare_soeiro_etal_IOC_2011.pdf309.69 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.