Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15970
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dc.contributor.authorBatista, Denise da G.J.
dc.contributor.authorSilva, Patrícia B. da
dc.contributor.authorStivanin, Luciene
dc.contributor.authorLachter, Daniela R.
dc.contributor.authorSilva, Renata S.
dc.contributor.authorFelcman, Judith
dc.contributor.authorLouro, Sonia R. W.
dc.contributor.authorTeixeira, Letícia R.
dc.contributor.authorSoeiro, Maria de Nazaré Correia
dc.date.accessioned2016-09-27T15:31:32Z
dc.date.available2016-09-27T15:31:32Z
dc.date.issued2011
dc.identifier.citationBATISTA, Denise da G. J. et al. Co(II), Mn(II) and Cu(II) complexes of fluoroquinolones: Synthesis, spectroscopical studies and biological evaluation against Trypanosoma cruzi. Polyhedron, v.30, n.10, p. 1718-1725, June 2011.
dc.identifier.issn0277-5387
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/15970
dc.language.isoeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subject.otherDoença de Chagas
dc.subject.otherTrypanosoma cruzi
dc.subject.otherQuimioterapia
dc.subject.otherFluoroquinolonas
dc.titleCo(II), Mn(II) and Cu(II) complexes of fluoroquinolones: Synthesis, spectroscopical studies and biological evaluation against Trypanosoma cruzi
dc.typeArticle
dc.identifier.doi10.1016/j.poly.2011.04.001
dc.description.abstracten[MnCl2(NOR)(H2O)2] (1), [MnCl2(SPAR)(H2O)2] (2), [CoCl2(NOR)(H2O)2] (3) [CoCl2(SPAR)(H2O)2] (4), [CuCl2(phen)(NOR)] (5) and [CuCl2(phen)(SPAR)] (6) complexes with norfloxacin (NOR) and sparfloxacin (SPAR) were obtained from MnCl2·4H2O, CoCl2·4H2O and CuCl2(phen). In all cases the NOR and SPAR coordinate in the neutral zwitterionic form. The electron paramagnetic resonance spectra of the Cu(II) complexes (5) and (6) in aqueous and DMSO solutions indicate mixture of mononuclear and binuclear complex. Complexes (1–6), together with the corresponding ligands were evaluated for their in vitro trypanocidal effect, against both bloodstream trypomastigotes and intracellular forms of Trypanosoma cruzi. SPAR and NOR were poorly effective upon T. cruzi, complexes (3) and (4) were active against intracellular forms of the parasite. The complexes (5) and (6) displayed a higher activity upon both bloodstream and intracellular forms. The potency of fluoroquinolones, specially those coordinated to Cu(II)–phen justify further trypanocidal screening assays with this compounds in vitro as well as upon experimental models of T. cruzi infection.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas Disease
dc.subject.enChemotherapy
dc.subject.enFluoroquinolones
dc.identifier.eissn1873-3719
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