Author | Vilas-Boas, Wendell | |
Author | Figueiredo, Camylla V. B. | |
Author | Pitanga, Thassila Nogueira | |
Author | Carvalho, Magda Oliveira Seixas | |
Author | Santiago, Rayra P. | |
Author | Santana, Sânzio Silva | |
Author | Guarda, Caroline Conceição da | |
Author | Zanette, Angela Maria Dias | |
Author | Cerqueira, Bruno Antonio Veloso | |
Author | Gonçalves, Marilda de Souza | |
Access date | 2017-02-13T12:20:03Z | |
Available date | 2017-02-13T12:20:03Z | |
Document date | 2016 | |
Citation | VILAS-BOAS, W. et al. Endothelial nitric oxide synthase (−786T.C) and endothelin-1 (5665G.T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia. Gene Regulation and Systems Biology, n.10, p. 67-72, 2016. | pt_BR |
ISSN | 1177-6250 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17795 | |
Description | We thank the patients for their participation because without them, this study would not have been conducted. | pt_BR |
Language | eng | pt_BR |
Publisher | Libertas Academica Journals | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Anemia Falciforme | pt_BR |
Subject in Portuguese | eNOS | pt_BR |
Title | Endothelial nitric oxide synthase (-786T>C) and endothelin-1 (5665G>T) gene polymorphisms as vascular dysfunction risk factors in sickle cell anemia | pt_BR |
Type | Article | pt_BR |
DOI | 10.4137/GRSB.S38276 | pt_BR |
Abstract | Sickle cell anemia (SCA) patients have vascular complications, and polymorphisms in endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) genes were associated with ET-1 and nitric oxide disturbance. We investigate the association of ET-1 5665G>T and eNOS -786T>C polymorphisms with soluble adhesion molecules (sVCAM-1 and sICAM-1), biochemical markers, and medical history. We studied 101 SCA patients; carriers of eNOS minor allele (C) had the highest levels of sVCAM-1, and carriers of ET-1 minor allele had more occurrence of acute chest syndrome (ACS). The multivariate analysis suggested the influence of the ET-1 gene on ACS outcome and an association of the eNOS gene with upper respiratory tract infection. We suggest that eNOS and ET-1 gene polymorphisms can influence SCA pathophysiology and that eNOS variant in SCA patients might be important to nitric oxide activity and vascular alteration. We found an association of the ET-1 minor allele in ACS, showing the importance of genetic screening in SCA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia da Bahia, Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade do Estado da Bahia, Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Analises Clínicas e Toxicologicas. Salvador, BA, Brasil. | pt_BR |
Subject | Sickle cell anemia | pt_BR |
Subject | eNOS | pt_BR |
Subject | Entothelin-1 | pt_BR |
Subject | Gene polymorphisms | pt_BR |
DeCS | Anemia Falciforme | pt_BR |