Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17846
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dc.contributor.authorAslan, Hamide
dc.contributor.authorOliveira, Fabiano
dc.contributor.authorMeneses, Claudio
dc.contributor.authorCastrovinci, Philip
dc.contributor.authorGomes, Regis
dc.contributor.authorTeixeira, Clarissa
dc.contributor.authorDerenge, Candace A.
dc.contributor.authorOrandle, Marlene
dc.contributor.authorGradoni, Luigi
dc.contributor.authorOliva, Gaetano
dc.contributor.authorFischer, Laurent
dc.contributor.authorValenzuela, Jesus G.
dc.contributor.authorKamhawi, Shaden
dc.date.accessioned2017-02-16T17:34:04Z
dc.date.available2017-02-16T17:34:04Z
dc.date.issued2016
dc.identifier.citationASLAN, Hamide et al. New insights into the transmissibility of Leishmania infantum from dogs to sand flies: experimental transmission reveals persistent parasite depots at bite sites. The Journal of Infectious Diseases, p.1752-1761, 1 June, 2016.
dc.identifier.issn1537-6613
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/17846
dc.language.isopor
dc.publisherMartin S. Hirsch
dc.rightsrestricted access
dc.subject.otherLeishmaniose canina
dc.subject.otherLeishmania infantum
dc.subject.otherLutzomyia longipalpis
dc.subject.otherReservatório
dc.subject.otherTransmissão vetorial
dc.subject.otherInfectividade
dc.titleNew insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites
dc.typeArticle
dc.description.abstractenCanine leishmaniasis (CanL) is a chronic fatal disease of dogs and a major source of human infection through propagation of parasites in vectors. Here, we infected 8 beagles through multiple experimental vector transmissions with Leishmania infantum–infected Lutzomyia longipalpis. CanL clinical signs varied, although live parasites were recovered from all dog spleens. Splenic parasite burdens correlated positively with Leishmania-specific interleukin 10 levels, negatively with Leishmania specific interferon γ and interleukin 2 levels, and negatively with Leishmania skin test reactivity. A key finding was parasite persistence for 6 months in lesions observed at the bite sites in all dogs. These recrudesced following a second transmission performed at a distal site. Notably, sand flies efficiently acquired parasites after feeding on lesions at the primary bite site. In this study, controlled vector transmissions identify a potentially unappreciated role for skin at infectious bite sites in dogs with CanL, providing a new perspective regarding the mechanism of Leishmania transmissibility to vector sand flies.
dc.creator.affilliationFaculty of Health Science. Selahaddin Eyyubi University. Diyarbakir, Turkey/ Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationComparative Medicine Branch. National Institute of Allergy and Infectious Diseases. National Institutes of Health,Rockville, Maryland, USA.
dc.creator.affilliationUnit of Vector-Borne Diseases and International Health. Istituto Superiore di Sanità. Rome. Italy.
dc.creator.affilliationDepartment of Veterinary Medicine and Animal Productions. University Federico II. Naples, Italy.
dc.creator.affilliationMerial S.A.S., R&D. Laboratoire de Lyon Gerland. Paris, France.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.creator.affilliationVector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
dc.subject.enCanine leishmaniasis
dc.subject.enLeishmania infantum
dc.subject.enLutzomyia longipalpis
dc.subject.enReservoir
dc.subject.enVector transmission
dc.subject.enInfectivity
Appears in Collections:PI - Artigos de Periódicos

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