Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17879
Title: Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
Authors: Martins, Darliane A.
Bomfim Filho, Lucius F.
Silva, Cleiton M. da
Fátima, Ângelo de
Louro, Sonia R. W.
Batista, Denise G. J.
Soeiro, Maria de Nazaré C.
Carvalho, João Ernesto de
Teixeira, Letícia R.
Affilliation: Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Campinas, SP, Brasil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil.
Abstract: Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino) phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.
Keywords: Schiff base
copper(II) complexes
biological activity
DNA
albumin
keywords: Albuminas
Base de schiff
Complexos de cobre (II)
DNA
Atividade biológica
Issue Date: 2016
Publisher: Instituto de Química - UNICAMP
Citation: MARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017.
DOI: 10.5935/0103-5053.20160150
ISSN: 0103-5053
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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