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Title: Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
Authors: Veras, Patrícia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
Affilliation: Fundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais. INCT-DT. Salvador, BA, Brasil
Abstract: Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival.
Keywords: Proteomics
Intracellular survival
keywords: Proteômica
Sobrevivência intracelular
Issue Date: 2016
Publisher: MDPI
Citation: VERAS, P. S. T.; MENEZES, J. P. B. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. International Journal of Molecular Sciences, v. 17, p. 1270, 2016.
DOI: 10.3390/ijms17081270
ISSN: 1661-6596
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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