Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health

Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.
Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins University. Welch Center for Prevention, Epidemiology and Clinical Research. Baltimore, MD, USA.
Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil / University of North Carolina. Department of Epidemiology. Chapel Hill, NC, USA.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. São Paulo, SP, Brasil / Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.
Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, USA / Johns Hopkins University. Welch Center for Prevention, Epidemiology and Clinical Research. Baltimore, MD, USA.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.
Universidade Federal do Rio Grande do Sul. Escola de Medicina. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil / University of North Carolina. Department of Epidemiology. Chapel Hill, NC, USA.

Resumen en ingles

Emerging evidence suggests sex differences in the early origins of adult metabolic disease, but this has been little investigated in developing countries. We investigated sex-specific associations between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetes was defined by self-reported information and laboratory measurements. In confounder-adjusted analyses, LBW (vs. 2.5-4 kg) was associated with higher prevalence of diabetes in women (Prevalence Ratio (PR) 1.54, 95% CI: 1.32-1.79), not in men (PR 1.06, 95% CI: 0.91-1.25; Pheterogeneity = 0.003). The association was stronger among participants with maternal diabetes (PR 1.60, 95% CI: 1.35-1.91), than those without (PR 1.15, 95% CI: 0.99-1.32; Pheterogeneity = 0.03). When jointly stratified by sex and maternal diabetes, the association was observed for women with (PR 1.77, 95% CI: 1.37-2.29) and without (PR 1.45, 95% CI: 1.20-1.75) maternal diabetes. In contrast, in men, LBW was associated with diabetes in participants with maternal diabetes (PR 1.45, 95% CI: 1.15-1.83), but not in those without (PR 0.92, 95% CI: 0.74-1.14). These sex-specific findings extended to continuous measures of glucose homeostasis. LBW was associated with higher diabetes prevalence in Brazilian women, and in men with maternal diabetes, suggesting sex-specific intrauterine effects on adult metabolic health.

Palabras clave en portugues

Epidemiologia
Fatores de Risco
Diabetes Tipo 2

Palabras clave en ingles

Epidemiology
Risk factors
Type 2 diabetes

Editor

Nature Publishing Group

Referencia

YARMOLINSKY, James et al. Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health. Scientific Reports, v. 6, p. 1-9, Nov. 2016.

DOI

10.1038/srep37032

ISSN

2045-2322

Por favor, use este identificador para citar o enlazar este ítem: https://www.arca.fiocruz.br/handle/icict/18102

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