Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18202
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dc.contributor.authorRaboni, Sonia M.
dc.contributor.authorBonfim, Carmem
dc.contributor.authorAlmeida, Bernardo M.
dc.contributor.authorZanluca, Camila
dc.contributor.authorKoishi, Andrea C.
dc.contributor.authorRodrigues, Paula R. V. P.
dc.contributor.authorKay, Claudia K.
dc.contributor.authorRibeiro, Lisandro L.
dc.contributor.authorScola, Rosana H.
dc.contributor.authorDuarte Dos Santos, Claudia N.
dc.date.accessioned2017-03-29T19:41:05Z
dc.date.available2017-03-29T19:41:05Z
dc.date.issued2017
dc.identifier.citationRaboni, Sonia M. etal. Flavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: A case report. Transplant Infectious Disease, p. 1-14, Mar. 2017
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/18202
dc.language.isoeng
dc.publisherWiley
dc.rightsopen access
dc.subject.otherVirus da Dengue
dc.subject.otherZika Virus
dc.subject.otherSíndrome de Guillain Barre
dc.titleFlavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: a case report
dc.typePreprint
dc.identifier.doi10.1111/tid.12700
dc.description.abstractenSerological diagnosis of flavivirus infection is a challenge, particularly in the context of a disease associated with immune response enhancement in a transplant patient, where aspects such as previous flavivirus infections may be involved with the outcome. We report a case of a pediatric patient who developed Guillain-Barré syndrome (GBS) after matched-unrelated hematopoietic stem cell transplantation (HSCT). The patient lives in a Brazilian region that is experiencing an epidemic of Zika virus (ZIKV) and dengue virus (DENV). Because an increasing number of cases of GBS, likely triggered by ZIKV infection, are being reported in Brazil, samples from the patient were tested for both ZIKV and DENV infection. Serological assays strongly suggested a recent ZIKV infection, although infection by DENV or co-infection with both viruses cannot be ruled out. The presence of anti-DENV immunoglobulin-G in donor serum led to the hypothesis that antibodies from the donor could have enhanced the severity of the ZIKV infection. This hypothesis is in agreement with the recent findings that DENV sero-cross-reactivity drives antibody-dependent enhancement of ZIKV infection. These findings highlight the need for discussion of the indication to perform previous flavivirus tests in HSCT donors, especially in areas where ZIKV and other flaviviruses co-circulate. This article is protected by copyright. All rights reserved.
dc.creator.affilliationUniversidade Federal do Paraná. Laboratório de Virologia. Paraná, PR, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Hospital de Epidemiologia. Paraná, PR, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil.
dc.creator.affilliationUniversidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
dc.subject.enGuillain-Barré Syndrome
dc.subject.enDengue Virus
dc.subject.enHematopoietic Stem Cell Transplantation
dc.subject.enZika virus
dc.peerreviewedNão
dc.publicationstatusNão Publicado
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