| Author | Bonaldo, Myrna C. | |
| Author | Gómez, Mariela Martínez | |
| Author | Santos, Alexandre A. C. dos | |
| Author | Abreu, Filipe Vieira Santos de | |
| Author | Brito, Anielly Ferreira de | |
| Author | Miranda, Rafaella Moraes de | |
| Author | Castro, Marcia Gonçalves de | |
| Author | Oliveira, Ricardo Lourenço de | |
| Access date | 2017-04-15T14:16:00Z | |
| Available date | 2017-04-15T14:16:00Z | |
| Document date | 2017 | |
| Citation | BONALDO, Myrna C. et al. Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphism. Mem Inst Oswaldo Cruz. E-pub: 4 Apr 2017. | pt_BR |
| ISSN | 1678-8080 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/18447 | |
| Language | spa | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vpirus da febre amarela | pt_BR |
| Subject in Portuguese | Surto de 2017 no Brasil | pt_BR |
| Subject in Portuguese | alterações de aminoácidos | pt_BR |
| Title | Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760170134 | |
| Abstract | The current yellow fever (YF) outbreak in Brazil is the most severe recently
reported in the country. It has rapidly spread to areas where YF viral activity have not
been observed for more than seventy years and vaccine coverage is almost null. Here,
we sequenced the whole YF genome of two naturally infected howler-monkeys
(Alouatta clamitans) from the Municipality of Domingos Martins, State of Espírito
Santo, Brazil. The ongoing-outbreak genome sequences are identical. They clustered in
1E sub-clade (South America I genotype) together with recent Brazilian and
Venezuelan strains characterized from infections in humans and non-humans primates.
However, we detected eight unique amino acid changes in the viral proteins, which are
located in the structural capsid protein (1 change), and the components of viral replicase
complex, the NS3 (2 changes) and NS5 (5 changes) proteins, suggesting a potential role
in the capacity of viral infection to vertebrate and/or invertebrate hosts and spreading in
the ongoing outbreak. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / Instituto Federal do Norte de Minas Gerais. MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | yellow fever virus | pt_BR |
| Subject | amino acids changes | pt_BR |
