Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18593
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dc.contributor.authorCassemiro, Klécia M. S. M.-
dc.contributor.authorBurlandy, Fernanda M.-
dc.contributor.authorSilva, Edson E. da-
dc.date.accessioned2017-04-20T14:08:50Z-
dc.date.available2017-04-20T14:08:50Z-
dc.date.issued2016-
dc.identifier.citationCASSEMIRO, Klécia M. S. M.; BURLANDY, Fernanda M.; SILVA, Edson E,. da. Rare natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus isolated from a case of acute flaccid paralysis in Brazil, 2015. Journal of General Virology, v.97, p.1545-1550, 2016.pt_BR
dc.identifier.issn0022-1317pt_BR
dc.identifier.urihttp://www.arca.fiocruz.br/handle/icict/18593-
dc.language.isoengpt_BR
dc.publisherMicrobiology Societypt_BR
dc.rightsrestricted accesspt_BR
dc.subject.otherPolioviruspt_BR
dc.subject.otherParalisia flácida agudapt_BR
dc.subject.otherAdministração oral da vacina contra o poliovíruspt_BR
dc.subject.otherBrasilpt_BR
dc.titleRare natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus isolated from a case of acute flaccid paralysis in Brazil, 2015pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1099/jgv.0.000484-
dc.description.abstractenA natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus was isolated from an acute flaccid paralytic case in Brazil. Genome sequencing revealed the uncommon location of the crossover site in the VP1 coding region (nucleotides 3251-3258 of Sabin 3 genome). The Sabin 2 donor sequence replaced the last 118 nt of VP1, resulting in the substitution of the complete antigenic site IIIa by PV2-specific amino acids. The low overall number of nucleotide substitutions in P1 region indicated that the predicted replication time of the isolate was about 8-9 weeks. Two of the principal determinants of attenuation in Sabin 3 genomes were mutated (U472C and C2493U), but the temperature-sensitive phenotype of the isolate was preserved. Our results support the theory that there exists a PV3/PV2 recombination hotspot site in the tail region of the VP1 capsid protein and that the recombination may occur soon after oral poliovirus vaccine administration.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.pt_BR
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.pt_BR
dc.subject.enpolioviruspt_BR
dc.subject.enacute flaccid paralysispt_BR
dc.subject.enoral poliovirus vaccine administrationpt_BR
dc.subject.enBrazilpt_BR
dc.subject.enPV3/PV2 recombination hotspot sitept_BR
dc.subject.enVP1 capsid proteinpt_BR
dc.identifier.eissn1465-2099-
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