Author | Freire, Cristina Pessoa Veloso | |
Author | Ferreira, Sabrina Baptista | |
Author | Oliveira, Nivea Suely Melo de | |
Author | Matsuura, Ani Beatriz Jackisch | |
Author | Gama, Ivson Lelis | |
Author | Silva, Fernando de C. da | |
Author | Souza, Maria Cecilia B. V. de | |
Author | Lima, Emerson Silva | |
Author | Ferreira, Vitor Francisco | |
Access date | 2011-04-06T11:15:13Z | |
Available date | 2011-04-06T11:15:13Z | |
Document date | 2010 | |
Citation | FREIRE, Cristina Pessoa Veloso et al. Synthesis and biological evaluation of substituted a- and b-2,3-dihydrofuran naphthoquinones as potent anticandidal agents. Med. Chem. Commun., v. 1, p. 229-232, 2010. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/1865 | |
Language | eng | pt_BR |
Rights | restricted access | pt_BR |
Title | Synthesis and biological evaluation of substituted a- and b-2,3-dihydrofuran naphthoquinones as potent anticandidal agents | pt_BR |
Type | Article | pt_BR |
DOI | 10.1039/c0md00074d | |
Abstract | We report herein, the synthesis and antifungal activity of substituted a- and b-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium(IV) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida (C.): C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. tropicalis and C. dubliniensis. In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these
fungi, indicating that they are important scaffolds and potential novel antifungal agents. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas Maria Deane. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil. | pt_BR |
Subject | Synthesis and Antifungal Activity | pt_BR |
Subject | Cerium(IV) Ammonium Nitrate (CAN) | pt_BR |
Subject | Potent Anticandidal Agents | pt_BR |