| Author | Costa, Giselle Calasans de Souza | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Azevedo, Rochele | |
| Author | Muricy, Gabriel | |
| Author | Kashima, Simone Haddad | |
| Author | Covas, Dimas Tadeu | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Gadelha, Sandra Rocha | |
| Access date | 2011-04-13T02:37:24Z | |
| Available date | 2011-04-13T02:37:24Z | |
| Document date | 2009 | |
| Citation | COSTA, G. C. S. et al. Frequency distribution of XbaIG > T and HaeIIIT > C GLUT1 polymorphisms among different Brazilian ethnic groups. Molecular Biology Reports, v.37, n.1, p. 75-79, 2010. | pt_BR |
| ISSN | 0301-4851 | |
| URI | https://www.arca.fiocruz.br/handle/icict/1897 | |
| Language | eng | pt_BR |
| Rights | open access | en |
| Title | Frequency distribution of XbaIG > T and HaeIIIT > C GLUT1 polymorphisms among different Brazilian ethnic groups | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s11033-009-9528-0 | |
| Abstract | GLUT is the major glucose transporter in mammalian cells. Single nucleotide polymorphisms (SNP) at GLUT1 promoter and regulatory regions have been associated to the risk of developing nephropathy in different type 1 and type 2 diabetic populations. It has been demonstrated that differences in allelic and genotypic frequencies of GLUT1 gene (SLC2A1) polymorphisms occur among different populations. Therefore, ethnic differences in distribution of GLUT1 gene polymorphisms may be an important factor in determining gene-disease association. In this study, we investigated the XbaIG > T and HaeIIIT > C polymorphisms in six different Brazilian populations: 102 individuals from Salvador population (Northern Brazil), 56 European descendants from Joinville (South Brazil), 85 Indians from Tiryió tribe (North Brazil) and 127 samples from Southern Brazil: 44 from European descendants, 42 from African descendants and 41 from Japanese descendants. Genotype frequencies from both sites did not differ significantly from those expected under the Hardy-Weinberg equilibrium. We verified that the allele frequencies of both polymorphisms were heterogeneous in these six Brazilian ethnic groups. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador,Bahia, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador,Bahia, Brasil | pt_BR |
| Affilliation | Laboratório de Biologia Molecular, Banco de Sangue Regional de Ribeirão Preto, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brasil | pt_BR |
| Affilliation | Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Laboratório de Biologia Molecular. Banco de Sangue Regional de Ribeirão Preto. São Paulo, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Laboratório de Biologia Molecular. Banco de Sangue Regional de Ribeirão Preto. São Paulo, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador,Bahia, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Santa Cruz, Campus Prof Soane Nazaré de Andrade, Ilheus, Bahia, Brazil | pt_BR |
| Subject | GLUT1 | pt_BR |
| Subject | Polymorphisms | pt_BR |
| Subject | Brazilian populations | pt_BR |
| DeCS | Desoxirribonucleases de Sítio Específico do Tipo II | pt_BR |
| DeCS | Grupos Étnicos | pt_BR |
| DeCS | Transportador de Glucose Tipo 1 | pt_BR |
| DeCS | Polimorfismo de Um Único Nucleotídeo | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Frequência do Gene | pt_BR |
