Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/19522
Title: The TGF-β Pathway as an Emerging Target for Chagas Disease Therapy
Authors: Araujo-Jorge, Tania C.
Waghabi, M. C.
Bailly, S.
Felge, J. J.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Institut National de la Santé et de la Recherche Médicale, Unité 1036. Biology of Cancer and Infection. Grenoble, France / Commissariat à l’Énergie Atomique et aux Energies Alternatives. Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier–Grenoble 1.Biology of Cancer and Infection. Grenoble, France.
Institut National de la Santé et de la Recherche Médicale, Unité 1036. Biology of Cancer and Infection. Grenoble, France / Commissariat à l’Énergie Atomique et aux Energies Alternatives. Institut de Recherches en Technologies et Sciences pour le Vivant. Grenoble, France / Université Joseph Fourier–Grenoble 1.Biology of Cancer and Infection. Grenoble, France
Abstract: Transforming growth factor-β (TGF-β) influences the development of myocardiopathy in Chagas disease through regulation of (i) parasite invasion of heart cells, (ii) an intracellular parasite cycle, (iii) inflammation and immune response, (iv) heart fibrosis and remodeling, and (v) gap junction modulation and heart conduction. In this review, we discuss the rationale for developing TGF-β signaling–interfering therapies as adjuvant approaches for the management of the cardiac alterations of Chagas disease-affected patients.
Keywords: Chagas Disease
Therapy
Transforming growth factor-β (TGF-β)
myocardiopathy
keywords: Doença de Chagas
Tratamento
Factor de crescimento de transformação β
Cardiomiopatias
Issue Date: 2012
Publisher: American Society for Clinical Pharmacology and Therapeutics
Citation: ARAÚJO-JORGE, T. C. et al. The TGF-β Pathway as an Emerging Target for Chagas Disease Therapy. Clinical Pharmacology & Therapeutcis, v.92, n.5, p.613-621, Nov. 2012.
ISSN: 0009-9236
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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