Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/19535
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dc.contributor.authorBarreto, Ana Virgínia Matos Sá
dc.contributor.authorAlecrim, Vinícius Martins
dc.contributor.authorMedeiros, Tibério Batista de
dc.contributor.authorDomingues, Ana Lúcia Coutinho
dc.contributor.authorLopes, Edmundo Pessoa
dc.contributor.authorMartins, João Roberto Maciel
dc.contributor.authorNader, Helena Bonciani
dc.contributor.authorDiniz, George Tadeu Nunes
dc.contributor.authorMontenegro, Silvia Maria Lucena
dc.contributor.authorMorais, Clarice Neuenschwander Lins de
dc.date.accessioned2017-06-27T17:40:46Z
dc.date.available2017-06-27T17:40:46Z
dc.date.issued2017
dc.identifier.citationBARRETO, A. V. M. S. et al. New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni. Arquivos De Gastroenterologia, v. 54, n. 1, p. 51–56, mar. 2017. DOI 10.1590/S0004-2803.2017v54n1-10.
dc.identifier.issn1678-4219
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/19535
dc.language.isopor
dc.rightsopen access
dc.subject.otherEsquistossomose mansoni
dc.subject.otherFibrose
dc.subject.otherCurva ROC
dc.titleNew index for the diagnosis of liver fibrosis in Schistosomiasis mansoni
dc.title.alternativeNovo índice biológico para o diagnóstico da fibrose hepática na Esquistossomose mansoni
dc.typeArticle
dc.identifier.doi10.1590/S0004-2803.2017v54n1-10
dc.description.abstractenBackground – Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. Objective – To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. Methods – Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey’s classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F). Results – Using multivariate analysis, a model was created, which involved alkaline phosphatase and platelets and could separate patients with different patterns of fibrosis. This index showed a better performance in separating patients without fibrosis from with advanced periportal fibrosis. The biological index showed an area under the ROC curve of 1.000. Using values below the lowest or above the highest cut-off point, the presence or absence of advanced fibrosis could be predicted in all patients. Conclusion – The index constructed can be used to separate patients with different patterns of periportal fibrosis, specially to predict advanced fibrosis in schistosomiasis patients.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
dc.subject.enAdolescent
dc.subject.enAdult
dc.subject.enAged
dc.subject.enAlkaline Phosphatase
dc.subject.enBiomarkers
dc.subject.enBlood Platelets
dc.subject.enCytokines
dc.subject.enFemale
dc.subject.engamma-Glutamyltransferase
dc.subject.enHumans
dc.subject.enHyaluronic Acid
dc.subject.enLiver Cirrhosis
dc.subject.enMale
dc.subject.enMiddle Aged
dc.subject.enPredictive Value of Tests
dc.subject.enSchistosomiasis mansoni
dc.subject.enSensitivity and Specificity
dc.subject.enSeverity of Illness Index
dc.subject.enTransaminases
dc.subject.enYoung Adult
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsIdoso
dc.subject.decsFosfatase Alcalina
dc.subject.decsBiomarcadores
dc.subject.decsPlaquetas
dc.subject.decsCitocinas
dc.subject.decsFeminino
dc.subject.decsHumanos
dc.subject.decsÁcido Hialurônico
dc.subject.decsÁcido Hialurônico
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsValor Preditivo dos Testes
dc.subject.decsEsquistossomose mansoni
dc.subject.decsSensibilidade e Especificidade
dc.subject.decsÍndice de Gravidade de Doença
dc.subject.decsTransaminases
dc.subject.decsAdulto Jovem
dc.subject.decsgama-Glutamiltransferase
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