Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20494
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dc.contributor.authorViana, Isabelle Freire Tabosa
dc.contributor.authorNascimento, Eduardo
dc.contributor.authorKrieger, Marco Aurélio
dc.contributor.authorCraigo, Jodi
dc.contributor.authorMailliard, Robbie
dc.contributor.authorRafael, Dhalia
dc.contributor.authorLins, Roberto
dc.contributor.authorMarques, Ernesto T. A.
dc.date.accessioned2017-08-02T16:37:35Z
dc.date.available2017-08-02T16:37:35Z
dc.date.issued2016
dc.identifier.citationVIANA, Isabelle Freire Tabosa et al. De Novo Design and Biophysical Characterization of an Affinity-Enhanced Protein Displaying the Structure of the Broadly Neutralizing HIV-1 2F5 Antibody Epitope. Biophysical Journal, v. 110 , n. 3, p. 346a, 2016.
dc.identifier.issn0006-3495
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/20494
dc.language.isopor
dc.publisherBiophysical Society
dc.rightsopen access
dc.subject.otherImunogenicidade da Vacina
dc.titleDe novo design and biophysical characterization of an Affinity-Enhanced Protein displaying the structure of the broadly neutralizing HIV-1 2F5 Antibody Epitope
dc.typeArticle
dc.identifier.doiorg/10.1016/j.bpj.2015.11.1860
dc.description.abstractenSuggest new approaches focus on engineer antigenic structures capable of exposing a stable conformation of these epitopes and thus inducing B-cell secretion of HIV-1 pnAbs. We postulated that conformationally stable structures are better immunogens and can elicit the production of better antibodies and results show that MD simulations can help engineer vaccine antigens capable of enhancing protective antibody responses.
dc.creator.affilliationCenter for Vaccine Research and Infectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.
dc.creator.affilliationMicrobiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
dc.creator.affilliationMicrobiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.
dc.creator.affilliationInfectious Diseases and Microbiology Department. University of Pittsburgh. Pittsburgh, PA, USA.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.
dc.creator.affilliationMicrobiology and Molecular Genetics Department. University of Pittsburgh. Pittsburgh, PA, USA.
dc.subject.enHIV-1
dc.subject.enHIV Antibodies
dc.subject.enVaccine
dc.subject.esVIH-1
dc.subject.esAnticuerpos Anti-VIH
dc.subject.esVacunal
dc.subject.decsHIV-1
dc.subject.decsAnticorpos Anti-HIV
dc.subject.decsVacina
Appears in Collections:PR - ICC - Artigos de Periódicos



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