Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20597
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dc.contributor.authorSantos, Flavia Almeida
dc.contributor.authorSilva, Regilane Matos da
dc.contributor.authorTome, Adriana da Rocha
dc.contributor.authorRao, Vietla S. N
dc.contributor.authorPompeu, Margarida Maria de Lima
dc.contributor.authorTeixeira, Maria Jania
dc.contributor.authorFreitas, Luiz Antonio Rodrigues de
dc.contributor.authorSouza, Valderes Lima de
dc.date.accessioned2017-08-11T17:51:35Z
dc.date.available2017-08-11T17:51:35Z
dc.date.issued2001
dc.identifier.citationSANTOS, F. A. et al. 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock. Journal of Pharmacy and Pharmacology, v. 53, p. 505-511, 2001.
dc.identifier.issn0022-3573
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/20597
dc.descriptionFreitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 300870/98-1).
dc.language.isoeng
dc.publisherWiley
dc.rightsopen access
dc.subject.otherInsuficiência hepática
dc.subject.otherChoque endotoxico
dc.subject.otherChoque septico
dc.subject.otherRatos
dc.subject.otherAnimais
dc.title1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock
dc.typeArticle
dc.description.abstractenThe effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg−1, i.p.) and LPS (5 lgkg−1, i.p.) greatly elevated serum concentrations of tumour necrosis factor-a (TNFa), alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic necrosis and lethality in 100% of control mice. Pretreatment with 1,8-cineole (400 mg kg−1, p.o.) and dexamethasone (1 mgkg−1, s.c.), 60 min before GalN/LPS, offered complete protection (100%) against the lethal shock and acute elevation in serum TNF-a and serum transaminases. Hepatic necrosis induced by GalN/LPS was also greatly reduced by both 1,8-cineole and dexamethasone treatment. The results indicate that 1,8-cineole protects mice against GalN/LPSinduced liver injury through the inhibition of TNF-a production, and suggest that 1,8-cineole may be a promising agent to combat septic-shock-associated pathologies.
dc.creator.affilliationFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
dc.creator.affilliationFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
dc.creator.affilliationFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
dc.creator.affilliationFederal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
dc.creator.affilliationFederal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza,
dc.creator.affilliationFederal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza,
dc.creator.affilliationFundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil
dc.subject.enHepatic failure
dc.subject.enEndotoxemic shock
dc.subject.enSeptic shock
dc.subject.enMice
dc.subject.enAnimals
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