Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20672
Title: Antigenic cross-reactivity of venoms obtained from snakes of genus bothrops
Authors: Silva, Ana Maria Moura da
Lima, Maria Regina D'Império
Nishikawa, Z. A. K
Brodskyn, Claudia Ida
Santos, Maria Cristina dos
Furtado, Maria de Fátima Domingues
Silva, Wilmar Dias da
Albuquerque, Ivan da Mota e
Affilliation: Instituto Butantan. Centro de Imunologia. São Paulo, SP, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Säo Paulo, SP, Brasil
Instituto Butantan. Secçäo de Concentração de Soros. São Paulo, SP, Brasil
Instituto Butantan. Centro de Imunologia. São Paulo, SP, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. Säo Paulo, SP, Brasil
Instituto Butantan. Seção de Venenos. São Paulo, SP, Brasil
Instituto Butantan. Laboratório Especial de Imunoquimica. São Paulo, SP, Brasil
Instituto Butantan. Centro de Imunologia. São Paulo, SP, Brasil
Abstract: Antigenic cross-reactivity was studied among the components of venoms from nine species of the genus Bothrops using species-specific antivenoms . Sera titration by DOT-ELISA detected similar levels of antibody when either homologous or heterologous antigens were used. Transblotted antigens, after SDS-PAGE fractionation, were also revealed by homologous and heterologous antivenoms . Antigens with mol. wt greater than 30,000 seemed to be the most cross-reactive . Antigens of about 24,000 mol. wt were poorly immunogenic. Antigens between 14-18,000 mol. wt cross-reacted only with B. moojeni, B.jararacussu, B. neuwiedi and B. pradoi venoms. Neutralization of the lethality of B. jararaca venom was observed by homologous and heterologous antivenoms .
Keywords: Bothrops
Snake venom
Snake venom
Animals
Elisa
keywords: Bothrops
Venenos de serpentes
Envenenamento por cobra
Animais
Elisa
Issue Date: 1990
Publisher: Elsevier
Citation: SILVA, A. M. M. et al. Antigenic cross-reactivity of venoms obtained from snakes of genus bothrops. Toxicon, v. 28, n. 2, p. 181-188, 1990.
Description: Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 0041-0101
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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