Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20842
Title: The ecology of the Trypanosoma cruzi transmission cycle: Dispersion of zymodeme 3 (Z3) in wild hosts from Brazilian biomes
Authors: Lisboa, Cristiane Varella
Xavier, Samanta Cristina das Chagas
Herrera, Heitor Miraglia
Jansen, Ana Maria
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil.
Abstract: Two main genotypes in Trypanosoma cruzi subpopulations can be distinguished by PCR amplification of sequences from the mini-exon gene non-transcribed spacer, respectively, T. cruzi I (TCI) and T. cruzi II (TCII). This technique is also capable of distinguishing a third assemblage of subpopulations that do not fit in these genotypes and that remain known as zymodeme Z3 (Z3). The distribution pattern as well as the mammalian host range of this latter T. cruzi sublineage still remains unclear. Thus, the intention of our study was to increase the information regarding these aspects. The mini-exon analysis of T. cruzi isolates obtained from sylvatic animals in the Amazon Forest, Atlantic Rainforest, Caatinga and Pantanal showed that prevalence of the Z3 subpopulation in nature was low (15 out of 225 isolates, corresponding to 7%). A higher prevalence of Z3 was observed in the Caatinga (15%) and the Pantanal (12%). Infection by Z3 was observed in mammalian hosts included in Carnivora, Chiroptera, Didelphimorphia, Rodentia and Xernathra. The T. cruzi Z3 subpopulation was observed also in mixed infections (33%) with TCI (n=2) and TCII (n=3). These results demonstrate that T. cruzi Z3 displays a wider distribution and host range than formerly understood as it has been demonstrated to be able infect species included in five orders of mammalian host species dispersed through all forest strata of the four Brazilian biomes evaluated.
Keywords: Trypanosoma cruzi
TCI, TCII and Z3 subpopulation
Wild hosts
keywords: Trypanosoma cruzi
Hospedeiros selvagens
Issue Date: 2009
Publisher: Elsevier
Citation: LISBOA, Cristiane Varella; et al. The ecology of the Trypanosoma cruzi transmission cycle: Dispersion of zymodeme 3 (Z3) in wild hosts from Brazilian biomes. Veterinary Parasitology, v.165, p.19–24, 2009.
DOI: 10.1016/j.vetpar.2009.07.002
ISSN: 0304-4017
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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