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https://www.arca.fiocruz.br/handle/icict/20991
PHOSPHODIESTERASE-5 INHIBITORS: ACTION ON THE SIGNALING PATHWAYS OF NEUROINFLAMMATION, NEURODEGENERATION, AND COGNITION
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Nerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
Affilliation
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract
Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.
Keywords in Portuguese
CogniçãoDegeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Keywords
CognitionNerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
DeCS
CogniçãoDegeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
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