Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23017
Title: Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase activity [correction for acitivity] in the hippocampus of survivor mice
Authors: Comim, Clarissa M.
Reis, Patrícia A.
Frutuoso, Valber S.
Fries, Gabriel R.
Fraga, Daiane B.
Kapczinski, Flávio
Zugno, Alexandra I.
Barichello, Tatiana
Quevedo, João
Faria Neto, Hugo C. Castro
Affilliation: Universidade do Sul de Santa Catarina. Programa de Pós-Graduação em Ciências da Saúde. Laboratório de Neurociências. Instituto Nacional de Medicina Translacional. Tubarão, SC, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Hospital de Clínicas de Porto Alegre. Centro de Pesquisas. Laboratório de Psiquiatria Molecular. Instituto Nacional de Medicina Translacional. Porto Alegre., RS, Brasil.,
Universidade do Sul de Santa Catarina. Programa de Pós-Graduação em Ciências da Saúde. Laboratório de Neurociências. Instituto Nacional de Medicina Translacional. Tubarão, SC, Brasil.
Hospital de Clínicas de Porto Alegre. Centro de Pesquisas. Laboratório de Psiquiatria Molecular. Instituto Nacional de Medicina Translacional. Porto Alegre., RS, Brasil.,
Universidade do Sul de Santa Catarina. Programa de Pós-Graduação em Ciências da Saúde. Laboratório de Neurociências. Instituto Nacional de Medicina Translacional. Tubarão, SC, Brasil.
Universidade do Sul de Santa Catarina. Programa de Pós-Graduação em Ciências da Saúde. Laboratório de Microbiologia Experimental. Instituto Nacional de Medicina Translacional. Tubarão, SC, Brasil.
Universidade do Sul de Santa Catarina. Programa de Pós-Graduação em Ciências da Saúde. Laboratório de Neurociências. Instituto Nacional de Medicina Translacional. Tubarão, SC, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Abstract: Malaria is the most important human parasitic disease and cerebral malaria (CM), its main neurological complication, is characterized by neurological and cognitive damage in both human and animal survivors. The brain-derived neurotrophic factor (BDNF) appears to be involved with activity-dependent synaptic plasticity. There is great interest regarding its role in learning and memory as well as acetylcholinesterase activity (AChE) that is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present work, we evaluated BDNF protein levels and AChE activity in the hippocampus and habituation in an animal model of CM using C57BL/6 mice after fifteen days of the induction. The results demonstrated that there was a decrease in BDNF levels in the hippocampus of C57BL/6 mice infected with PbA when compared with C57BL/6 non-infected mice and C57BL/6 non-infected mice that received treatment with chloroquine. However, no difference was observed in AChE activity in the hippocampus. When habituation was evaluated there was memory impairment in the C57BL/6 mice infected with Plasmodium berghei ANKA (PbA). In conclusion, we believe that the decreased BDNF levels in the hippocampus may be related with memory impairment without alterations on AChE activity.
Keywords: Cerebral malaria
BDNF
AChE
Brain
Memory
Mice
keywords: Malária cerebral
Cerebro
Memória
Ratos
Fator Neurotrófico Derivado do Encéfalo
Dor
Issue Date: 2012
Publisher: Elsevier
Citation: COMIM, Clarissa M. et al. Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase acitivity in the hippocampus of survivor mice. Neuroscience Letters, v.523, n.2, p.104-107, 2012.
DOI: 10.1016/j.neulet.2012.06.051
ISSN: 0304-3940
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
valber_frutuoso_etal_IOC_2012.pdf217.62 kBAdobe PDF    Request a copy



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.