Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23370
Title: Pharmacological Basis for Traditional Use of the Lippia thymoides
Authors: Silva, Fabrício Souza
Menezes, Pedro Modesto Nascimento
de Sá, Pedro Guilherme Souza
Oliveira, André Luís de Santana
Souza, Eric Alencar Araújo
Bamberg, Vinicius Martins
de Oliveira, Henrique Ribeiro
de Oliveira, Sheilla Andrade
Araújo, Roni Evêncio E
Uetanabaro, Ana Paula Trovatti
Silva, Tânia Regina Dos Santos
Almeida, Jackson Roberto Guedes da Silva
Lucchese, Angélica Maria
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: The aim of this study was to evaluate crude extracts and fractions from leaves and stems of Lippia thymoides and to validate their use in folk medicine. In vitro antioxidant and antimicrobial activities and in vivo wound healing in rats, baker yeast-induced fever in young rats, and acute oral toxicity in mice assays were realized. The crude extracts and their dichloromethane and ethyl acetate fractions had potent radical-scavenging activity against the DPPH but were not effective in the β-carotene bleaching method. The dichloromethane fraction from the leaves extract showed the broadest spectrum of activity against S. aureus, B. cereus, and C. parapsilosis. The animals treated with crude extracts showed no difference in wound healing when compared with the negative control group. The crude extract from leaves (1200 mg/kg) has equal efficacy in reducing temperature in rats with hyperpyrexia compared to dipyrone (240 mg/kg) and is better than paracetamol (150 mg/kg). In acute toxicity test, crude extract of leaves from Lippia thymoides exhibited no mortality and behavioral changes and no adverse effects in male and female mice. This work validates the popular use of Lippia thymoides for treating the wound and fever, providing a source for biologically active substances.
Keywords: Lippia
Oils, Volatile
Fever
Mice
Wounds and Injuries
keywords: Lippia
Óleos voláteis
Ferimentos e Lesões
Febre
DeCS: Lippia
Óleos voláteis
Ferimentos e Lesões
Febre
Camundongos
Issue Date: 2015
Citation: SILVA, F. S. et al. Pharmacological Basis for Traditional Use of the Lippia thymoides. Evidence-Based Complementary and Alternative Medicine: eCAM, v. 2015, p. 463248, 2015.
DOI: 10.1155/2015/463248
ISSN: 1741-427X
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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