Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23657
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dc.contributor.authorCruz, Heidi Lacerda Alves da
dc.contributor.authorSilva, Ronaldo Celerino da
dc.contributor.authorSegat, Ludovica
dc.contributor.authorCarvalho, Márcia Schneider Zuzarte de Mendonça Gomes de
dc.contributor.authorBrandão, Lucas André Cavalcanti
dc.contributor.authorGuimarães, Rafael Lima
dc.contributor.authorSantos, Fabiana Cristina Fulco
dc.contributor.authorLira, Laís Ariane Siqueira de
dc.contributor.authorMontenegro, Lilian Maria Lapa
dc.contributor.authorSchindler, Haiana Charifker
dc.contributor.authorCrovella, Sergio
dc.date.accessioned2017-12-14T12:46:20Z
dc.date.available2017-12-14T12:46:20Z
dc.date.issued2013
dc.identifier.citationCRUZ, H. L. A. da et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, v. 19, p. 323–329, out. 2013.
dc.identifier.issn1567-7257
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/23657
dc.language.isoeng
dc.rightsopen access
dc.subject.otherTuberculose
dc.subject.otherImunidade inata
dc.subject.otherMBL2
dc.subject.otherPulmonar
dc.subject.otherPolimorfismos
dc.titleMBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population
dc.typeArticle
dc.identifier.doi10.1016/j.meegid.2013.03.002
dc.description.abstractenThe innate immune system represents the first line of host defense against pathogens. Genetics factors regulating the immune responses play a role in the susceptibility to infectious diseases, such as tuberculosis (TB). We analyzed MBL2 promoter and exon 1 functional single nucleotide polymorphisms (SNPs) in a group of 155TB patients and 148 healthy controls in order to evaluate their influence on the onset of infection and TB development. There was no association between MBL2 -550 HL promoter polymorphisms and susceptibility to develop TB, but heterozygous -221 Y/X genotype was significantly more frequent in pulmonary TB patients than controls. Moreover, MBL2 exon 1 O allele, was significantly associated with susceptibility to TB development in general (p=0.023, OR=1.61, 95% CI 1.05-2.49) and pulmonary TB (p=0.0008, OR=2.16, 95% CI 1.35-3.46); C allele at codon 57, as well as A/C genotype, were significantly more frequent in TB patients than in controls. Our results indicate that MBL2 polymorphisms, especially at codon 57, could be considered as risk factors for TB development.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
dc.creator.affilliationFederal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil.
dc.creator.affilliationInstitute for Maternal and Child Health. Trieste, Italy.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil / Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil / Federal University of Pernambuco. Department of Pathology. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Department of Genetics. Recife, PE, Brazil / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami. Recife, PE, Brazil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de imunologia. Recife, PE, Brasil.
dc.creator.affilliationInstitute for Maternal and Child Health. Trieste, Italy.
dc.subject.enTuberculosis
dc.subject.enInnate immunity
dc.subject.enMBL2
dc.subject.enPulmonary
dc.subject.enPolymorphisms
dc.subject.decsPredisposição Genética para Doença
dc.subject.decsgenética
dc.subject.decsLectina de Ligação a Manose
dc.subject.decsgenética
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsBrasil
dc.subject.decsepidemiologia
dc.subject.decsEstudos de Casos e Controles
dc.subject.decsFeminino
dc.subject.decsGenótipo
dc.subject.decsHumanos
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsPolimorfismo de Nucleotídeo Único
dc.subject.decsgenética
dc.subject.decsTuberculose Pulmonar
dc.subject.decsepidemiologia
dc.subject.decsTuberculose Pulmonar
dc.subject.decsgenética
dc.subject.decsAdulto Jovem
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