Author | Rodríguez, N. E. | |
Author | Lockard, R. D. | |
Author | Turcotte, E. A. | |
Author | Santos, T. Araújo | |
Author | Bozza, P. T. | |
Author | Borges, V. M. | |
Author | Wilson, M. E. | |
Access date | 2018-02-20T16:54:33Z | |
Available date | 2018-02-20T16:54:33Z | |
Document date | 2017 | |
Citation | RODRIGUEZ, N. E. et al. Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages. Parasite Immunology, v.39, e12443, 5p, 2017. | pt_BR |
ISSN | 0141-9838 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24890 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Leishmania | pt_BR |
Subject in Portuguese | Gotículas Lipídicas | pt_BR |
Subject in Portuguese | Macrófagos | pt_BR |
Subject in Portuguese | protozoário parasita | pt_BR |
Title | Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/pim.12443 | |
Abstract | Lipid bodies (LBs) are intracellular accumulations of neutral lipids surrounded by a single membrane. These organelles are involved in the production of eicosanoids, which modulate immunity by either promoting or dampening inflammatory responses. Leishmania infantum, the etiological agent of visceral leishmaniasis in Brazil, is an intracellular parasite that causes disease by suppressing macrophage microbicidal responses. C57BL/6 mouse bone marrow-derived macrophages infected with L. infantum strain LcJ had higher numbers of LB+ cells (P<.0001) and total LBs than noninfected cultures. Large (>3 μm) LBs were present inside parasitophorous vacuoles (PVs). These results contrast with those of L. infantum-infected BALB/c macrophages, in which the only LBs are derived from parasite, not macrophage origin. Increased LBs in C57BL/6 macrophages in close association with parasites would position host LBs where they could modulate L. infantum infection. These results imply a potential influence of the host genetics on the role of LBs in host-pathogen interactions. Overall, our data support a model in which the expression, and the role of LBs upon infection, ultimately depends on the specific combination of host-pathogen interactions. | pt_BR |
Affilliation | University of Northern Iowa. Department of Biology. Cedar Falls, IA, USA. | pt_BR |
Affilliation | University of Northern Iowa. Department of Biology. Cedar Falls, IA, USA. | pt_BR |
Affilliation | University of Northern Iowa. Department of Biology. Cedar Falls, IA, USA. | pt_BR |
Affilliation | Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Diniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | University of Iowa. Department of Internal Medicine. Iowa City, IA, USA / University of Iowa. Department of Microbiology. Iowa City, IA, USA / Veterans’ Affairs Medical Center. Iowa City, IA, USA. | pt_BR |
Subject | Leishmania | pt_BR |
Subject | lipid bodies | pt_BR |
Subject | macrophage | pt_BR |
Subject | protozoan parasite | pt_BR |
e-ISSN | 1365-3024 | |
Embargo date | 2030-01-01 | |