Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25295
Full metadata record
DC FieldValue
dc.contributor.authorZanluca, Camila
dc.contributor.authorNoronha, Lucia de
dc.contributor.authorSantos, Claudia Nunes Duarte dos
dc.date.accessioned2018-03-13T18:00:03Z
dc.date.available2018-03-13T18:00:03Z
dc.date.issued2018
dc.identifier10.1080/21688370.2017.1402143
dc.identifier.citationZANLUCA, Camila; NORONHA, Lucia de; SANTOS, Claudia Nunes dos. Maternal-fetal transmission of the zika virus: an intriguing interplay. Tissue Barriers, v.6, n.1, p. 1-31, 2018.
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25295
dc.language.isoeng
dc.publisherTaylor & Francis
dc.rightsrestricted access
dc.titleMaternal-fetal transmission of the zika virus: An intriguing interplay
dc.typePreprint
dc.description.abstractenIn this review, we give an overview of aspects related to the congenital transmission of the Zika virus (ZIKV). Although we acknowledge that important advances in research on ZIKV pathogenesis have come from studies using animal models, particularly non-human primates, this review emphasizes studies using ex-vivo human cells and tissues as well as natural infections in pregnant women. The possible routes used by ZIKV to cross or breach the placental barrier and infect the fetal central nervous system are presented. Understanding the viral infection biology and ZIKV pathogenesis during pregnancy may guide the design of affordable antiviral strategies to benefit pregnant women in areas at risk.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
dc.creator.affilliationPontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental, PR, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
dc.subject.enHofbauer cells
dc.subject.enZika Virus
dc.subject.enPlacental Barriers
dc.subject.enMaternal-Fetal Transmission
dc.subject.enNatural Infections
dc.subject.enEx Vivo Models
dc.peerreviewedSim
dc.publicationstatusPublicado
Appears in Collections:PR - ICC - Preprint

Files in This Item:
File Description SizeFormat 
Mater_fetal_Zik.pdf1.66 MBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.