Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25710
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dc.contributor.authorBorges, Andrezza Raposo
dc.contributor.authorAires, Juliana Ramos de Albuquerque
dc.contributor.authorHigino, Taciana Mirely Maciel
dc.contributor.authorMedeiros, Maria das Graças Freire de
dc.contributor.authorCitó, Antonia Maria das Graças Lopes
dc.contributor.authorLopes, José Arimatéia Dantas
dc.contributor.authorFigueiredo, Regina Celia Bressan Queiroz de
dc.date.accessioned2018-04-10T12:38:02Z
dc.date.available2018-04-10T12:38:02Z
dc.date.issued2012
dc.identifier.citationBORGES, A. R. et al. Trypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil. Experimental Parasitology, v. 132, n. 2, p. 123–128, out. 2012.
dc.identifier.issn1090-2449
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25710
dc.description.sponsorshipEste trabalho foi apoiado pela CAPES e CPqAM - FIOCRUZ .
dc.language.isoeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subject.otherÓleos essenciais
dc.subject.otherTrypanosoma cruzi
dc.subject.otherDoença de Chagas
dc.subject.otherQuimioterapia
dc.subject.otherCitotoxicidade
dc.titleTrypanocidal and cytotoxic activities of essential oils from medicinal plants of Northeast of Brazil
dc.typeArticle
dc.identifier.doi10.1016/j.exppara.2012.06.003
dc.description.abstractenChagas disease, caused by Trypanosoma cruzi, is an important cause of mortality and morbidity in Latin America. There are no vaccines available, the chemotherapy used to treat this illness has serious side effects and its efficacy on the chronic phase of disease is still a matter of debate. In a search for alternative treatment for Chagas disease, essential oils extracted from traditional medicinal plants Lippia sidoides, Lippia origanoides, Chenopodium ambrosioides, Ocimum gratissimum, Justicia pectorales and Vitex agnus-castus were investigated in vitro for trypanocidal and cytotoxic activities. Essential Oils were extracted by hydrodistillation and submitted to chemical analysis by gas chromatography/mass spectrometry. The concentration of essential oils necessary to inhibit 50% of the epimastigotes or amastigotes growth (IC(50)) and to kill 50% of trypomastigote forms (LC(50)) was estimated. The most prevalent chemical constituents of these essential oils were monoterpenes and sesquiterpenes. All essential oils tested demonstrated an inhibitory effect on the parasite growth and survival. L. sidoides and L. origanoides essential oils were the most effective against trypomastigote and amastigote forms respectively. No significant cytotoxic effects were observed in mouse peritoneal macrophages incubated with essential oils which were more selective against the parasites than mammalian cells. Taken together, our results point towards the use of these essential oils as potential chemotherapeutic agent against T. cruzi.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
dc.creator.affilliationUniversidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil.
dc.creator.affilliationUniversidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil.
dc.creator.affilliationUniversidade Federal do Piauí. Campus Universitário Ministro Petrônio Portela-Ininga. Departamento de Química. Teresina, PI, Brazil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Microbiologia. Recife, PE, Brasil.
dc.subject.enEssential oils
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas disease
dc.subject.enChemotherapy
dc.subject.enCytotoxicity
dc.subject.decsAcanthaceae / química
dc.subject.decsAnimais
dc.subject.decsBrasil
dc.subject.decsCélulas Cultivadas
dc.subject.decsChenopodium ambrosioides / química
dc.subject.decsCitotoxinas / efeitos adversos
dc.subject.decsCitotoxinas / farmacologia
dc.subject.decsCromatografia Gasosa-Espectrometria de Massa
dc.subject.decsConcentração Inibidora 50
dc.subject.decsMacrófagos Peritoneais / efeitos de drogas
dc.subject.decsMacrófagos Peritoneais / parasitologia
dc.subject.decsRatos
dc.subject.decsRatos, endogâmicos BALB C
dc.subject.decsOcimum / química
dc.subject.decsÓleos voláteis / química
dc.subject.decsÓleos voláteis / isolamento e purificação
dc.subject.decsÓleos Voláteis / Farmacêuticos
dc.subject.decsPlantas Medicinais / Química
dc.subject.decsTripanocidas Agentes / efeitos adversos
dc.subject.decsTripanocidas Agentes / Farmacologia
dc.subject.decsTrypanosoma cruzi / efeitos de drogas
dc.subject.decsVerbenaceae / química
Appears in Collections:PE - IAM - Artigos de Periódicos

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