Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25737
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dc.contributor.authorVilella, Marília
dc.contributor.authorCosta, Gustavo Nunes de Oliveira
dc.contributor.authorBarreto, Maurício Lima
dc.contributor.authorFigueredo, Camila Alexandrina
dc.contributor.authorNeves, Neuza Maria Alcantara
dc.contributor.authorRodrigues, Laura Cunha
dc.contributor.authorMatos, Sheila Maria Alvim de
dc.contributor.authorFiaccone, Rosemeire Leovigildo
dc.contributor.authorOliveira, Pablo
dc.contributor.authorRocha, Aline
dc.contributor.authorSilva, Rita de Cássia Ribeiro
dc.date.accessioned2018-04-10T16:51:15Z
dc.date.available2018-04-10T16:51:15Z
dc.date.issued2017
dc.identifier.citationVILELLEA, M. et al. Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study. British Journal of Nutrition, v. 117, p. 1503–1510, 2017.
dc.identifier.issn0007-1145
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25737
dc.description.sponsorshipFunding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil), the Brazilian National Research Council (CNPq) and The Wellcome Trust, UK, Ref 072405/Z/03/Z.
dc.language.isoeng
dc.publisherCambridge University Press
dc.rightsopen access
dc.subject.otherIngestão dietética
dc.subject.otherVariantes do FTO
dc.subject.otherAdiposidade
dc.subject.otherCrianças
dc.titleEffect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study
dc.typeArticle
dc.identifier.doi10.1017/S0007114517001386
dc.description.abstractenPrevious studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.
dc.creator.affilliationUniversidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Department of Epidemiology and Population Health. London, UK
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Escola de Nutrição. Departamento Ciência da Nutrição. Salvador, BA, Brasil
dc.subject.enDietary intake
dc.subject.enFTO variants
dc.subject.enAdiposity
dc.subject.enChildren
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