Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25826
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dc.contributor.authorMariz, Fernanda Pinto
dc.contributor.authorCarvalho, Luciana Rodrigues
dc.contributor.authorMello, Wallace de
dc.contributor.authorAraújo, Alexandra de Queiroz Campos
dc.contributor.authorRibeiro, Márcia Gonçalves
dc.contributor.authorCunha, Maria do Carmo Soares Alves
dc.contributor.authorVoit, Thomas
dc.contributor.authorButler-Browne, Gillian
dc.contributor.authorBarbosa, Suse Dayse Silva
dc.contributor.authorSavino, Wilson
dc.date.accessioned2018-04-12T17:10:11Z
dc.date.available2018-04-12T17:10:11Z
dc.date.issued2010
dc.identifier.citationMARIZ, Fernanda Pinto; et al. Differential integrin expression by T lymphocytes: Potential role in DMD muscle damage. JOurnal of Neuroimmunology, v.223, p.128-130, 2010.
dc.identifier.issn0165-5728
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25826
dc.language.isoeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subject.otherDistrofia Muscular de Duchenne
dc.subject.otherMovimento Celular
dc.subject.otherIntegrinas
dc.subject.otherFibronectinas
dc.subject.otherLinfócitos T
dc.titleDifferential integrin expression by T lymphocytes: potential role in DMD muscle damage
dc.typeArticle
dc.identifier.doi10.1016/j.jneuroim.2010.03.006
dc.description.abstractenThe expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3(+)CD4(+) and CD3(+)CD8(+) defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4(+) and CD8(+) T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Traumatologia e Ortopedia. Centro de Pesquisa em Bioengenharia Ortopédica e Terapia Celular. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversité Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
dc.creator.affilliationUniversité Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
dc.subject.enDuchenne muscular dystrophy
dc.subject.enT lymphocytes
dc.subject.enIntegrins
dc.subject.enFibronectin
dc.subject.enCell migration
dc.identifier.eissn1872-8421
Appears in Collections:IOC - Artigos de Periódicos

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