Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25835
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dc.contributor.authorSouza, Bruno Solano de Freitas
dc.contributor.authorSilva, Daniela Nascimento
dc.contributor.authorCarvalho, Rejane Hughes
dc.contributor.authorSampaio, Gabriela Louise de Almeida
dc.contributor.authorParedes, Bruno Diaz
dc.contributor.authorAragão França, Luciana
dc.contributor.authorAzevedo, Carine Machado
dc.contributor.authorVasconcelos, Juliana Fraga
dc.contributor.authorMeira, Cássio Santana
dc.contributor.authorChenaud Neto, Paulo
dc.contributor.authorMacambira, Simone Garcia
dc.contributor.authorSilva, Kátia Nunes da
dc.contributor.authorAllahdadi, Kyan James
dc.contributor.authorTavora, Fabio
dc.contributor.authorSouza Neto, João David de
dc.contributor.authorSantos, Ricardo Ribeiro dos
dc.contributor.authorSoares, Milena Botelho Pereira
dc.date.accessioned2018-04-13T14:04:28Z
dc.date.available2018-04-13T14:04:28Z
dc.date.issued2017
dc.identifier.citationSOUZA, B. S. F. et al. Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. American Journal of Pathology, v. 187, n. 5, p. 1134-1146, 2017.
dc.identifier.issn0002-9440
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25835
dc.description.sponsorshipNational Council for Scientific and Technological Development and Bahia Research Foundation.
dc.language.isoeng
dc.publisherElsevier
dc.rightsopen access
dc.subject.otherCardiomiopatia chagásica
dc.subject.otherGalectina 3
dc.subject.otherTrypanosoma cruzi
dc.subject.otherDoença de Chagas
dc.subject.otherInflamação
dc.titleAssociation of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy
dc.typeArticle
dc.identifier.doi10.1016/j.ajpath.2017.01.016
dc.description.abstractenChronic Chagas disease cardiomyopathy, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Galectin-3 (Gal-3) has been linked to cardiac remodeling and poor prognosis in heart failure of different etiologies. Herein, we investigated the involvement of Gal-3 in the disease pathogenesis and its role as a target for disease intervention. Gal-3 expression in mouse hearts was evaluated during T. cruzi infection by confocal microscopy and flow cytometry analysis, showing a high expression in macrophages, T cells, and fibroblasts. In vitro studies using Gal-3 knockdown in cardiac fibroblasts demonstrated that Gal-3 regulates cell survival, proliferation, and type I collagen synthesis. In vivo blockade of Gal-3 with N-acetyl-d-lactosamine in T. cruzi-infected mice led to a significant reduction of cardiac fibrosis and inflammation in the heart. Moreover, a modulation in the expression of proinflammatory genes in the heart was observed. Finally, histological analysis in human heart samples obtained from subjects with Chagas disease who underwent heart transplantation showed the expression of Gal-3 in areas of inflammation, similar to the mouse model. Our results indicate that Gal-3 plays a role in the pathogenesis of experimental chronic Chagas disease, favoring inflammation and fibrogenesis. Moreover, by demonstrating Gal-3 expression in human hearts, our finding reinforces that this protein could be a novel target for drug development for Chagas cardiomyopathy.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFederal University of Bahia. Salvador, BA, Brasil / Messejana Heart and Lung Hospital. Fortaleza, CE, Brazil
dc.creator.affilliationFederal University of Bahia. Salvador, BA, Brasil / Messejana Heart and Lung Hospital. Fortaleza, CE, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enChagasic Cardiomyopathy
dc.subject.enGalectin-3
dc.subject.enTrypanosoma cruzi
dc.subject.enChagas disease
dc.subject.enInflammation
Appears in Collections:BA - IGM - Artigos de Periódicos

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