Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25850
Title: Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors
Authors: Lima, Sandro G. de
Albuquerque, Maria de F. P. M. de
Oliveira, João R. M. de
Ayres, Constância F. J.
Cunha, José E. G. da
Oliveira, Danyllo F. de
Lemos, Roberta R. de
Souza, Manuela B. R. de
Silva, Odwaldo B. e
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Federal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Federal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
Federal University of Pernambuco. Department of Clinical Medicine. Recife, PE, Brazil.
Abstract: The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.
Keywords: Exaggerated blood pressure response
Genes
Hypertension
Risk Factors
keywords: Resposta exagerada da pressão arterial
Genes
Hipertensão
Fatores de risco
DeCS: Adolescente
Adulto
Envelhecido
Angiotensinogênio / genética
Pressão Arterial / genética
Pressão Arterial / fisiologia
Estudos de coorte
Teste de Exercício
Fêmea
Estudos de associação genética
Hemodinâmica / genética
Hemodinâmica / fisiologia
Humanos
Hipertensão / genética
Hipertensão / fisiopatologia
Mutação INDEL
Masculino
Meia idade
Peptidil-Dipeptidase A / genética
Polimorfismo Genético
Fatores de risco
Adulto jovem
Issue Date: 2012
Citation: DE LIMA, S. G. et al. Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors. Hypertension Research, v. 35, n. 7, p. 733–738, jul. 2012.
DOI: 10.1038/hr.2012.14
ISSN: 1348-4214
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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