Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25850
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dc.contributor.authorLima, Sandro G. de
dc.contributor.authorAlbuquerque, Maria de Fátima Pessoa Militão de
dc.contributor.authorOliveira, João R. M. de
dc.contributor.authorAyres, Constância F. J.
dc.contributor.authorCunha, José E. G. da
dc.contributor.authorOliveira, Danyllo F. de
dc.contributor.authorLemos, Roberta R. de
dc.contributor.authorSouza, Manuela B. R. de
dc.contributor.authorSilva, Odwaldo B. e
dc.date.accessioned2018-04-16T13:31:26Z
dc.date.available2018-04-16T13:31:26Z
dc.date.issued2012
dc.identifier.citationLIMA, Sandro G. de et al. Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors. Hypertension Research, v. 35, n. 7, p. 733–738, jul. 2012.
dc.identifier.issn1348-4214
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25850
dc.description.sponsorshipEste trabalho foi financiado pela FACEPE.
dc.language.isoeng
dc.rightsrestricted access
dc.subject.otherResposta exagerada da pressão arterial
dc.subject.otherGenes
dc.subject.otherHipertensão
dc.subject.otherFatores de risco
dc.titleExaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors
dc.typeArticle
dc.identifier.doi10.1038/hr.2012.14
dc.description.abstractenThe factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
dc.creator.affilliationFederal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
dc.creator.affilliationFederal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Keizo Asami Laboratory. Recife, PE, Brazil.
dc.creator.affilliationFederal University of Pernambuco. Department of Clinical Medicine. Recife, PE, Brazil.
dc.subject.enExaggerated blood pressure response
dc.subject.enGenes
dc.subject.enHypertension
dc.subject.enRisk Factors
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsEnvelhecido
dc.subject.decsAngiotensinogênio / genética
dc.subject.decsPressão Arterial / genética
dc.subject.decsPressão Arterial / fisiologia
dc.subject.decsEstudos de coorte
dc.subject.decsTeste de Exercício
dc.subject.decsFêmea
dc.subject.decsEstudos de associação genética
dc.subject.decsHemodinâmica / genética
dc.subject.decsHemodinâmica / fisiologia
dc.subject.decsHumanos
dc.subject.decsHipertensão / genética
dc.subject.decsHipertensão / fisiopatologia
dc.subject.decsMutação INDEL
dc.subject.decsMasculino
dc.subject.decsMeia idade
dc.subject.decsPeptidil-Dipeptidase A / genética
dc.subject.decsPolimorfismo Genético
dc.subject.decsFatores de risco
dc.subject.decsAdulto jovem
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