Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25918
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dc.contributor.authorRibeiro, Mayara
dc.contributor.authorFranco, Priscila Silva
dc.contributor.authorMaria, Janice Buiate Lopes
dc.contributor.authorAngeloni, Mariana Bodini
dc.contributor.authorBarbosa, Bellisa de Freitas
dc.contributor.authorGomes, Angelica de Oliveira
dc.contributor.authorCastro, Andressa Silva
dc.contributor.authorSilva, Rafaela José da
dc.contributor.authorOliveira, Fernanda Chaves de
dc.contributor.authorMilian, Iliana Claudia Balga
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorIetta, Francesca
dc.contributor.authorMineo, José Roberto
dc.contributor.authorFerro, Eloisa Amália Vieira
dc.date.accessioned2018-04-17T19:36:05Z
dc.date.available2018-04-17T19:36:05Z
dc.date.issued2017
dc.identifier.citationRIBEIRO, Mayara et al. Azithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells. Exp Parasitol., v. 181, p. 111-118, 2017
dc.identifier.issn0014-4894
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/25918
dc.language.isoeng
dc.publisherAcademic Press
dc.rightsrestricted access
dc.subject.otherazitromicina
dc.subject.otherToxoplasmose
dc.titleAzithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells
dc.typeArticle
dc.identifier.doi10.1016/j.exppara.2017.08.004
dc.description.abstractenTrophoblast infection by Toxoplasma gondii plays a pivotal role in the vertical transmission of toxoplasmosis. Here, we investigate whether the antibiotic therapy with azithromycin, spiramycin and sulfadiazine/pyrimethamine are effective to control trophoblast infection by two Brazilian T. gondii genotypes, TgChBrUD1 or TgChBrUD2. Two antibiotic protocols were evaluated, as follow: i) pre-treatment of T. gondii-tachyzoites with selected antibiotics prior trophoblast infection and ii) post-treatment of infected trophoblasts. The infection index/replication and the impact of the antibiotic therapy on the cytokine milieu were characterized. It was observed that TgChBrUD2 infection induced lower infection index/replication as compared to TgChBrUD1. Regardless the therapeutic protocol, azithromycin was more effective to control the trophoblast infection with both genotypes when compared to conventional antibiotics. Azithromycin induced higher IL-12 production in TgChBrUD1-infected cells that may synergize the anti-parasitic effect. In contrast, the effectiveness of azithromycin to control the TgChBrUD2-infection was not associated with the IL-12 production. BeWo-trophoblasts display distinct susceptibility to T. gondii genotypes and the azithromycin treatment showed to be more effective than conventional antibiotics to control the T. gondii infection/replication regardless the parasite genotype
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Instituto de Ciencias Biologicas. Departamento de Biologia Estrutural. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto René Rachou. Laboratorio de Doença de Chagas. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversity of Siena. Department of Life Science. Aldo Moro Road 2, Siena, Italy
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Imunologia, Microbiologia e Parasitologia. Laboratorio de Imunoparasitologia. Uberlândia, MG, Brazil
dc.creator.affilliationUniversidade Federal de Uberlândia. Departamento de Histologia e Embriologia. Laboratorio de Imunofisiologia Reprodutiva. Uberlândia, MG, Brazil
dc.subject.enTrophoblast cell
dc.subject.enAzithromycin
dc.subject.enToxoplasma gondii atypical strains
dc.subject.enCytokines
Appears in Collections:MG - IRR - Artigos de Periódicos



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