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2030-01-01
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- INI - Artigos de Periódicos [3497]
- IOC - Artigos de Periódicos [12791]
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MMP-9 ACTIVITY IS INDUCED BY LEISHMANIA BRAZILIENSIS INFECTION AND CORRELATES WITH MUCOSAL LEISHMANIASIS
Leishmaniose tegumentar americana
Macrófagos
Metaloproteinase de matriz
Matrix metalloproteinase
Leishmania braziliensis
Macrophages
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Los Angeles Biomedical research Institute of Harbour-UCLA Miedical Center. Department of Medicine. Divisions of Dermatology and Adult Infections Disease. Torrance, CA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Los Angeles Biomedical research Institute of Harbour-UCLA Miedical Center. Department of Medicine. Divisions of Dermatology and Adult Infections Disease. Torrance, CA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.
Los Angeles Biomedical research Institute of Harbour-UCLA Miedical Center. Department of Medicine. Divisions of Dermatology and Adult Infections Disease. Torrance, CA, USA.
Abstract
Infection of humans with Leishmania braziliensis typically results in localized cutaneous leishmaniasis (LCL). Rarely, after months or years of apparent clinical cure, some patients develop the destructive mucosal leishmaniasis (ML). ML results from L. braziliensis dissemination, probably via phagocytic cells. As the preferred cells for Leishmania spp. colonization, macrophages are critical to infection control, and may contribute to parasite dissemination. However, the host factors that determine this outcome are unknown. Matrix metalloproteinase 9 (MMP-9) is known to be important for immune cell migration, macrophage recruitment, and effective granuloma formation. Moreover, MMP-9 has been involved in Mycobacterium tuberculosis dissemination. Here, we demonstrate that in vitro infection of human macrophages with L. braziliensis increased the secretion and activation of MMP-9. We also demonstrate that macrophages from healthy cured individuals with previous history of ML had increased MMP-9 activity compared to LCL cured individuals. These findings may represent a fundamental difference in host innate immunity that could contribute to the clinical leishmaniasis presentation.
Keywords in Portuguese
Leishmania braziliensisLeishmaniose tegumentar americana
Macrófagos
Metaloproteinase de matriz
Keywords
American tegumentary leishmaniasisMatrix metalloproteinase
Leishmania braziliensis
Macrophages
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