Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25962
Title: Apoptosis of non-parasitized red blood cells in malaria: a putative mechanism involved in the pathogenesis of anaemia
Authors: Totino, Paulo R. R.
Magalhães, Aline D.
Silva, Luciene A.
Banic, Dalma M.
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Abstract: Severe anaemia is a common complication of Plasmodium falciparum malaria in hyperendemic regions. Premature elimination of non-parasitized red blood cells (nRBC) has been considered as one mechanism involved in the genesis of severe malaria anaemia. It has been reported that apoptosis can occur in RBC and, consequently, this cell death process could contribute to anaemia. This study was performed to evaluate the susceptibility of nRBC to apoptosis in a malaria anaemia murine model.
Keywords: Malaria
Anaemia
Plasmodium falciparum
keywords: Malária
Anemia
Plasmodium falciparum
Issue Date: 2010
Publisher: BioMed Central
Citation: TOTINO, Paulo Renato R. et al. Apoptosis of non-parasitized red blood cells in malaria: a putative mechanism involved in the pathogenesis of anaemia. Malaria Journal, v.9:150, 5p, 2010.
DOI: 10.1186/1475-2875-9-350
ISSN: 1475-2875
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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