Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26090
Title: Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: The Bambui-Epigen Study
Authors: Costa, Maria Fernanda Lima
Mambrini, Juliana Vaz de Melo
Torres, Karen Cecilia Lima
Peixoto, Sérgio William Viana
Andrade, Fabíola Bof
Oliveira, Cesar de
Santos, Eduardo Tarazona
Carvalho, Andrea Teixeira de
Martins Filho, Olindo Assis
Affilliation: Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
University College London. Department of Epidemiology & Public Health. London, UK
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brazil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Abstract: Background: The ability of inflammatory markers to predict disability in later life has received growing attention. However, the current evidence came predominantly from Caucasians and the role of genomic ancestry has not been investigated. Objective: We investigated the prognostic value of multiple citokynes and chemokines for incident disability in admixed older Brazilians and whether genomic African and Native American ancestry affects the association. Design: Population-based longitudinal study. Setting: The Bambui-Epigen (Brazil) Cohort Study of Aging. Subjects: 1171 males and females aged ≥60 years over 15-year of follow-up. Methods: Outcome examined was incident activity of daily living (ADL) disability assessed annually (10,039 measures were performed). Serum levels of citokynes (IL6, IL12, TNF, IL10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) were measured at baseline. We used 370,539 Single Nucleotide Polymorphisms (SNPs) to estimate each individual genomic ancestry proportions. Potential confounding variables included a wide range of socio-demographic variables and health indicators. Statistical analyses were based on competing risk framework. Results: The incidence rate of disability was 57.9 per 1000 person-years. IL6 level at the highest quartile showed an independent association with ADL disability (SRH = 1.32; 95% CI: 1.03, 1.70). Other inflammatory markers showed no statistically significant associations with the outcome. Neither genomic African nor Native American ancestry had an effect modifier on the associations (P for interaction >0.05 for all). Conclusion: Among multi-inflammatory markers, only IL6 had the potential to identify people at increased risk of ADL disability, independently of ethno-racial background
Keywords: Inflammation
Activity of daily living
Genomic african ancestry
Ageing
Disability
Interleukin
keywords: inflamação
Atividades Cotidianas
Issue Date: 2017
Publisher: Elsevier
Citation: COSTA, Maria Fernanda Lima. Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: The Bambui-Epigen Study. Arch Gerontol Geriatr., v. 72, p. 103-107, 2017
DOI: 10.1016/j.archger.2017.05.013
ISSN: 0167-4943
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos



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