Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2614
Title: Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil
Authors: Faria, Marcos Tucunduva de
Calderwood, Michael S
Athanazio, Daniel Abensur
McBride, Alan John Alexander
Hartskeerl, Rudy A
Pereira, Martha Maria
Ko, Albert Icksang
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Brigham and Women’s Hospital. Department of Medicine. Boston, United States of America
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Royal Tropical Institute. Department of Biomedical Research. Amsterdam, The Netherlands
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ri de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: A survey was conducted to identify reservoirs for urban leptospirosis in the city of Salvador, Brazil. Sampling protocols were performed in the vicinity of households of severe leptospirosis cases identified during active hospital-based surveillance. Among a total of 142 captured Rattus norvegicus (Norwegian brown rat), 80.3% had a positive culture isolate from urine or kidney specimens and 68.1% had a positive serum sample by microscopic agglutination test (MAT) titre of > or = 1:100. Monoclonal antibody-based typing of isolates identified that the agent carried by rats was Leptospira interrogans serovar Copenhageni, which was the same serovar isolated from patients during hospital-based surveillance. Leptospira spp. were not isolated from 8 captured Didelphis marsupialis (Opossum), while 5/7 had a positive MAT titre against a saprophytic serogroup. R. rattus were not captured during the survey. The study findings indicate that the brown rat is a major rodent reservoir for leptospirosis in this urban setting. Furthermore, the high carriage rates of L. interrogans serovar Copenhageni in captured rats suggest that there is a significant degree of environmental contamination with this agent in the household environment of high risk areas, which in turn is a cause of transmission during urban epidemics.
Keywords: Leptospira
Rats
Poverty Areas
DeCS: Leptospirose
Leptospira interrogan
Reservatórios de Doenças
Portador Sadio
Testes de Aglutinação
Técnicas de Tipagem Bacteriana
Sorotipagem
Ratos
Saude da População Urbana
Brasil
Issue Date: 2008
Citation: FARIA, M. T. et al. Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Tropica, v, 108, n. 1, p. 1-5, Oct. 2008.
DOI: 10.1016/j.actatropica.2008.07.005
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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