Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26142
Title: Would selenium supplementation aid in therapy for Chagas disease?
Authors: Jelicks, Linda A.
Souza, Andréa P. de
Araujo-Jorge, Tania C.
Tanowitz, Herbert B.
Affilliation: Albert Einstein College of Medicine. Department of Physiology and Biophysics. New York, NY, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil.
Albert Einstein College of Medicine. Department of Pahology and Medicine. New York, NY, USA.
Abstract: Chagas disease, a neglected tropical disease discovered over 100 years ago, is caused by the intracellular parasite Trypanosoma cruzi and is most frequently associated with chronic cardiomyopathy and digestive disorders. Initial invasion of cells is followed by progressive inflammatory destruction of heart, muscles, nerves, and gastrointestinal (GI) tract tissue. Approximately 30% of patients progress to a chronic cardiomyopathy associated with increased morbidity and mortality. Seven to 10% of patients develop megasyndromes involving the GI tract, in particular, the esophagus and the colon. Results from several studies suggest that selenium (Se) deficiency could be an important factor in the pathogenesis of Chagas disease. In this opinion article, Se supplementation is proposed as an adjuvant therapy for treatment of chronic Chagas disease.
Keywords: Chagas Disease
Trypanosoma cruzi
selenium supplementation
therapy
keywords: Doença de Chagas
Trypanosoma cruzi
Tratamento
suplementação de selênio
Issue Date: 2011
Publisher: Elsevier
Citation: JELICKS, Linda A. et al. Would selenium supplementation aid in therapy for Chagas Disease?. Trends Parasitol., v. 27, n.3, p.102–105, Mar. 2011.
DOI: 10.1016/j.pt.2010.12.002
ISSN: 1471-4922
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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