Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2615
Full metadata record
DC FieldValue
dc.contributor.authorReis, Joice Neves
dc.contributor.authorPalma, Tania
dc.contributor.authorRibeiro, Guilherme de Sousa
dc.contributor.authorPinheiro, Ricardo M.
dc.contributor.authorRibeiro, Cássio Tâmara
dc.contributor.authorCordeiro, Soraia Machado
dc.contributor.authorSilva Filho, Hermes Pedreira da
dc.contributor.authorMoschioni, Monica
dc.contributor.authorThompson, Terry A
dc.contributor.authorSpratt, Brian G
dc.contributor.authorRiley, Lee Woodland
dc.contributor.authorBarocchi, Michele A
dc.contributor.authorReis, Mitermayer Galvão dos
dc.contributor.authorKo, Albert Icksang
dc.date.accessioned2011-05-06T00:01:27Z
dc.date.available2011-05-06T00:01:27Z
dc.date.issued2008
dc.identifier.citationREIS, J. N. et al. Transmission of Streptococcus pneumoniae in an Urban Slum Community. Journal of Infection, v.57, n.3, p. 204-213, Sept. 2008.
dc.identifier.issn0163-4453
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/2615
dc.language.isoeng
dc.rightsopen access
dc.titleTransmission of Streptococcus pneumoniae in an Urban Slum Community
dc.typeArticle
dc.identifier.doi10.1016/j.jinf.2008.06.017
dc.description.abstractenInhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5-18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2-6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis.The study's findings indicate that there is significant intra- and inter-household spread of S. pneumoniae in the slum community setting. However, a limited number of clones encountered during carriage among slum residents were found to cause invasive disease.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationNovartis Vaccines. Siena, Italia
dc.creator.affilliationCenters for Disease Control and Prevention. Streptococcus Laboratory. Atlanta, United States of America
dc.creator.affilliationImperial College. Department of Infectious Disease Epidemiology. London, UK
dc.creator.affilliationSchool of Public Health, University of Califórnia. Division of Infectious Diseases. Berkeley, CA, United States of America
dc.creator.affilliationNovartis Vaccines. Siena, Italia
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enStreptococcus pneumoniae
dc.subject.enNasopharyngeal Carriage
dc.subject.enpneumococcal conjugate vaccines
dc.subject.enAntibiotic Resistance
dc.subject.enUrban Slums
dc.subject.decsStreptococcus pneumoniae
dc.subject.decsVacinas Pneumocócicas
dc.subject.decsPortador Sadio
dc.subject.decsTécnica de Tipagem Bacteriana
dc.subject.decsDNA Bacteriano
dc.subject.decsFarmacorresistência Bacteriana
dc.subject.decsVacinas Meningocócicas
dc.subject.decsÁreas de Pobreza
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Transmission of Streptococcus pneumoniae in an Urban.pdf315.87 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.