Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26288
Title: Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV transmission by Vector Bite to Vertebrate Host
Authors: Chaves, Barbara Aparecida
Orfano, Alessandra Silva
Nogueira, Paula Monalisa
Rodrigues, Nilton Barnabe
Campolina, Thais Bonifácio
Pimenta, Rafael Nacif
Pires, Ana Clara Araújo Machado
Vieira Júnior, Ademir Bentes
Paz, Andréia da Costa
Vaz, Evelyn Beatriz da Costa
Guerra, Maria das Graças Vale Barbosa
Silva, Breno Melo
Melo, Fabrício Freire de
Norris, Douglas Eric
Lacerda, Marcus Vinícius Guimarães de
Pimenta, Paulo Filemon Paolucci
Secundino, Nágila Francinete Costa
Affilliation: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Departmento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Bahia, Brasil.
The W. Harry Feinstone. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/undação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/undação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
Abstract: Background. Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results. A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions. This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
Keywords: Coinfection
Aedes aegypti
Zika virus
dengue virus
preferential transmission
vector bite
keywords: coinfecção
Aedes aegypti
Zika virus
dengue virus
Issue Date: 2018
Publisher: University of Chicago Press
Citation: CHAVES, Barbara Aparecida et al. Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV transmission by Vector Bite to Vertebrate Host. J Infect Dis., 2018
DOI: 10.1093/infdis/jiy196
ISSN: 0022-1899
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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