Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26426
Title: MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases?
Authors: Moreira, Marcela de Lima
Tsuji, Moriya
Corbett, Alexandra Jane
Araújo, Márcio Sobreira Silva
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Pascoal, Vanessa Peruhype Magalhães
Reis, Jordana Grazziela Coelho dos
Affilliation: Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Aaron Diamond AIDS Research Center. The Rockefeller University, New York, NY, USA
Department of Microbiology and Immunology. Peter Doherty Institute for Infection and Immunity. University of Melbourne. Melbourne, Australia
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil
Abstract: It has been almost two decades since the discovery of mucosal-associated invariant T (MAIT)-cells. Several advances in the field have been made such as the discovery of the antimicrobial activity of MAIT-cells, the abundance of these cells in human mucosa and in liver and the discovery of ligands able to bind MR1 and activate MAIT-cells. MAIT-cells are a unique subset of innate-like T-cells that express a canonical T-cell receptor with the alpha chain containing hAV7S2 and AJ33 in humans (TCRVα7.2Jα33) and respond to bacterial/fungus vitamin B2 metabolites by an MR1-dependent pathway. Indirect activation is also observed during chronic viral infections by and IL-12/IL-18 pathway. In this review, the mechanisms of activation, the timeline of MAIT-cell development in humans as well as their role in human infection are discussed. On the whole, we believe that harnessing the anti-microbial ability of MAIT-cells could contribute for the design of potent immunotherapies and vaccines against “hard-to-kill” infectious agents that remain as public health threats worldwide
Keywords: MAIT-cells
MR1
TCRVα7.2
TRAV1-2
CD161
Infectious diseases
keywords: MAIT-celulas
MR1
TCRVα7.2
CD161 I
Issue Date: 2017
Publisher: Elsevier
Citation: MOREIRA, Marcela de Lima et al. MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases? Immunol Lett., v. 187, p. 53-60, 2017.
DOI: 10.1016/j.imlet.2017.05.007
ISSN: 0165-2478
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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