Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26437
Title: Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
Authors: Silva, Thiago Magalhães da
Fiaccone, Rosemeire L
Kehdye, Fernanda de Souza Gomes
Santos, Eduardo Martin Tarazona
Rodrigues, Laura C
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila A
Neves, Neuza Maria Alcantara
Barreto, Maurício Lima
Affilliation: Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brazil
Universidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology. Department of Infectious Disease Epidemiology. London, United Kingdom
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil
Abstract: Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Similarly, studies comparing the association of BGA and self-reported skin colour with these determinants are scarce. Here, we report the association of BGA and self-reported skin colour with socioenvironmental conditions and infections. We studied 1246 children living in a Brazilian urban poor area. The BGA was estimated using 370,539 genome-wide autosomal markers. Standardised questionnaires were administered to the children’s guardians to evaluate socioenvironmental conditions. Infection (or pathogen exposure) was defined by the presence of positive serologic test results for IgG to seven pathogens (Toxocara spp, Toxoplasma gondii, Helicobacter pylori, and hepatitis A, herpes simplex, herpes zoster and Epstein-Barr viruses) and the presence of intestinal helminth eggs in stool samples (Ascaris lumbricoides and Trichiuris trichiura). African ancestry was negatively associated with maternal education and household income and positively associated with infections and variables, indicating poorer housing and living conditions. The self-reported skin colour was associated with infections only. In stratified analyses, the proportion of African ancestry was associated with most of the outcomes investigated, particularly among admixed individuals. In conclusion, BGA was associated with socioenvironmental conditions and infections even in a low-income and highly admixed population, capturing differences that self-reported skin colour miss. Importantly, our findings suggest caution in interpreting significant associations between BGA and diseases as indicative of the genetic factors involved.
Keywords: Antecedentes biogeográficos
Desigualdades raciais
Status socioeconômico
Infecções
keywords: Biogeographical ancestry
Racial inequalities
Socioeconomic status
Infections
Issue Date: 2018
Publisher: Elsevier
Citation: SILVA, T. M. et al. Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population. SSM - Population Health, v. 4, p. 301–306, 2018.
ISSN: 2352-8273
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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