Mostrar el registro sencillo del ítem

AutorCuesta-Astroza, Yesid
AutorOliveira, Francislon Silva de
AutorNahum, Laila Alves
AutorOliveira, Guilherme Correa de
Fecha de acceso2018-05-21T17:55:14Z
Fecha de disponibilización2018-05-21T17:55:14Z
Fecha de publicación2017
ReferenciaCUESTA-ASTROZ, Yesid et al. Helminth secretomes reflect different lifestyles and parasitized hosts. Int J Parasitol., v. 47, n. 9, p. 529-544, 2017pt_BR
ISSN0020-7519pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/26530
Idiomaengpt_BR
EditorElsevier Sciencept_BR
Derechos de autorrestricted accesspt_BR
Palabras clave en PortuguésSecretomept_BR
Palabras clave en PortuguésEvolução de proteínaspt_BR
Palabras clave en Portuguésbiodiversidadept_BR
Palabras clave en Portuguésinteração parasito-hospedeiropt_BR
Palabras clave en Portuguésbiologia computacionalpt_BR
Palabras clave en Portuguéshelmintospt_BR
TítuloHelminth secretomes reflect different lifestyles and parasitized hosts.pt_BR
Tipo del documentoArticle
DOI10.1016/j.ijpara.2017.01.007
Resumen en InglésHelminths cause a number of medical and agricultural problems and are a major cause of parasitic infections in humans, animals and plants. Comparative analysis of helminth genes and genomes are important to understand the genomic biodiversity and evolution of parasites and their hosts in terms of different selective pressures in their habitats. The interactions between the infective organisms and their hosts are mediated in large part by secreted proteins, known collectively as the “secretome”. Proteins secreted by parasites are able to modify a host's environment and modulate their immune system. The composition and function of this set of proteins varies depending on the ecology, lifestyle and environment of an organism. The present study aimed to predict, in silico, the secretome in 44 helminth species including Nematoda (31 species) and Platyhelminthes (13 species) and, understand the diversity and evolution of secretomes. Secretomes from plant helminths range from 7.6% (943 proteins) to 13.9% (2,077 proteins) of the filtered proteome with an average of 10.2% (1,412 proteins) and from free-living helminths range from 4.4% (870 proteins) to 13% (3,121 proteins) with an average of 9.8% (2,126 proteins), respectively, and thus are considerably larger secretomes in relation to animal helminth secretomes which range from 4.2% (431 proteins) to 11.8% (2,419 proteins) of the proteomes, with an average of 7.1% (804 proteins). Across 44 secretomes in different helminth species, we found five conserved domains: (i) PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain), (ii) PF00046 (Homeobox domain), (iii) PF00188 (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins), (iv) PF00085 (Thioredoxin) and (v) PF07679 (Immunoglobulin I-set domain). Our results detected secreted proteins associated with invasion, infection, adhesion and immunoregulation processes as protease inhibitors and cytokines, among other functions. In summary, this study will contribute towards the understanding of host-parasite interactions and possibly identify new molecular targets for the treatment or diagnosis of helminthiases.pt_BR
AfiliaciónUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Faculdade Promove de Tecnologia. Belo Horizonte, MG, Brazilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Instituto Tecnológico Vale. Belém, PA, Brazilpt_BR
Palavras clave en InglêsSecretomept_BR
Palavras clave en InglêsProtein evolutionpt_BR
Palavras clave en InglêsBiodiversitypt_BR
Palavras clave en InglêsHost-parasite interactionpt_BR
Palavras clave en InglêsComputational biologypt_BR
Palavras clave en InglêsHelminthspt_BR
Fecha de embargo2024-01-01
xmlui.metadata.dc.subject.ods15 Vida terrestre


Ficheros en el ítem

application/pdf
Nombre:
Helminth secretomes reflect ...
Tamaño:
14.87Mb
Formato:
application/
Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem