| Author | Resende, Sarah Stela | |
| Author | Milagres, Vanessa Gonçalves | |
| Author | Chaves, Daniel Gonçalves | |
| Author | Fontes, Cor Jesus Fernandes | |
| Author | Carvalho, Luzia Helena de | |
| Author | Sousa, Tais Nobrega de | |
| Author | Brito, Cristiana Ferreira Alves de | |
| Access date | 2018-05-22T19:34:37Z | |
| Available date | 2018-05-22T19:34:37Z | |
| Document date | 2017 | |
| Citation | RESENDE, Sarah Stela et al. Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection. Infect Genet Evol., v. 50, p. 87-92, 2017. | pt_BR |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26561 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Science | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Plasmodium vivax | pt_BR |
| Subject in Portuguese | Malaria | pt_BR |
| Subject in Portuguese | Anemia | pt_BR |
| Subject in Portuguese | ABO blood group | pt_BR |
| Title | Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.meegid.2017.03.001 | |
| Abstract | Plasmodium vivax has been reported to cause severe malaria, and one of the main resulting complications is anemia. Considering that P. vivax infects only young erythrocytes, anemia has been associated with the destruction of infected and non-infected erythrocytes. However, few studies have focused on understanding the relationship between the pathogenesis of P. vivax malaria and human genetic polymorphisms. Although ABO groups seem to influence the outcome of Plasmodium falciparum malaria, the association between P. vivax and ABO blood groups has been minimally investigated. Thus, we investigate the correlation between ABO blood groups and anemia induced by P. vivax infection. Five single nucleotide polymorphisms at the ABO gene were genotyped by PCR-RFLP and Real-Time PCR in P. vivax-infected subjects. The ABO blood types were associated with the hematological data of the patients. Our main finding was that type O infected-individuals showed lower levels of hemoglobin and hematocrit compared to type A-infected individuals. The correlation between ABO blood groups and hemoglobin levels remained significant when a multiple linear regression was applied with the possible confounding effects of clinical-epidemiologic variables taken into account. The finding that type O individuals have a higher frequency of anemia is a first step to understand the mechanisms involved in malaria anemia, which could be associated to increased destruction of type O erythrocytes. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Hemominas. Serviço de Pesquisa. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso. Hospital Julio Muller. Cuiabá, MT, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Anemia | pt_BR |
| Subject | ABO blood group | pt_BR |
| Embargo date | 2024-01-01 | |
