Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26885
Title: Synergic and antagonistic relationship between MMP-2 and MMP-9 with fibrosis and inflammation in Chagas' cardiomyopathy
Authors: Medeiros, Nayara Ingrid de
Estanislau, Juliana de Assis Silva Gomes
Oliveira, Rodrigo Correa de
Affilliation: Fundação Oswaldo Cruz. Instituo René Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituo René Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
Abstract: Cardiomyopathy is the most important clinical manifestation in the chronic phase of Chagas' disease because of its frequency, severity and impact on morbidity and mortality. The extracellular matrix degradation during cardiac remodeling in Trypanosoma cruzi infection is driven by matrix metalloproteinases (MMPs), primarily the MMP-2 and MMP-9 gelatinases. MMPs also regulate some molecules related to inflammation, such as growth factors, cytokines and chemokines. The involvement of MMP-2 and MMP-9 is not yet fully understood in Chagas' disease. It has been proposed that the gelatinases may have opposite effect on inflammation/regulation and cardiac remodeling. MMP-2 would participate in regulation, offering a protective role for cardiac damage in asymptomatic patients and would be a good marker for the initiation of changes in the heart. On the other hand, MMP-9 can be used as a marker for serious changes on the heart and would be associated with inflammation and fibrosis. Here, we consolidate all characteristics involving MMP-2 and MMP-9 in Chagas' disease based on current studies to clarify their participation on the inflammation/regulation and fibrosis, and the synergistic or antagonistic role between them.
Keywords: Chagas' Cardiomyopathy
cardiac remodeling
cytokines
fibrosis
inflammation
matrix metalloproteinases
keywords: cardiopatia chagásica
remodelagem cardíaca
citocinas
fibrose
inflamação
Issue Date: 2017
Publisher: Blackwell Publishing
Citation: MEDEIROS, Nayara Ingrid de; ESTANISLAU, Juliana de Assis Silva Gomes; OLIVEIRA, Rodrigo Correa de. Synergic and antagonistic relationship between MMP-2 and MMP-9 with fibrosis and inflammation in Chagas' cardiomyopathy. Parasite Immunol, v.39, n. 8, e12446, 2017
DOI: 10.1111/pim.12446
ISSN: 0141-9838
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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