Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27197
Title: Correlation between TH1 response standard cytokines as biomarkers in patients with the delta virus in the western Brazilian Amazon.
Authors: Nicolete., Larissa Deadame de Figueiredo.
Borzacov., Lourdes Maria Pinheiro.
Vieira., Deusilene Souza.
Nicolete., Roberto.
Salcedo., Juan Miguel Villalobos.
Affilliation: Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil. / Fundação Oswaldo Cruz. Laboratório de Biotecnologia Aplicada à Saúde. Porto Velho, RO, Brasil.
Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil.
Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil. / Fundação Oswaldo Cruz. Laboratório de Biotecnologia Aplicada à Saúde. Porto Velho, RO, Brasil.
Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Fundação Oswaldo Cruz. Laboratório de Biotecnologia Aplicada à Saúde. Porto Velho, RO, Brasil.
Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. / Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brasil. / Fundação Oswaldo Cruz. Laboratório de Biotecnologia Aplicada à Saúde. Porto Velho, RO, Brasil.
Abstract: Hepatitis D virus (HDV) is endemic in the Amazon Region and its pathophysiology is the most severe among viral hepatitis. Treatment is performed with pegylated interferon and the immune response appears to be important for infection control. HDV patients were studied: untreated and polymerase chain reaction (PCR) positive (n = 9), anti-HDV positive and PCR negative (n = 8), and responders to treatment (n = 12). The cytokines, interleukin (IL)-2 (p = 0.0008) and IL-12 (p = 0.02) were differentially expressed among the groups and were also correlated (p = 0.0143). Future studies will be conducted with patients at different stages of treatment, associating the viral load with serum cytokines produced, thereby attempting to establish a prognostic indicator of the infection.
Keywords: HDV
TH1 cytokines
Patients treated
Issue Date: 2016
Publisher: Memórias do Instituto Oswaldo Cruz.
Citation: SALCEDO, Juan Miguel Villalobos, et all. Correlation between TH1 response standard cytokines as biomarkers in patients with the delta virus in the western Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, vol.111, p.275-276, 2016.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:RO - Artigos de Periódicos




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