Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27359
Title: Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-2016
Authors: Almeida, Isabel Marlúcia Lopes Moreira de
Ramos, Carmen Viana
Rodrigues, Danielle Carvalho
Sousa, Amanda Carvalho de
Nascimento, Maria de Lourdes Cristina Alcântara Paz Carvalho do
Silva, Marcos Vilhena Bittencourt da
Batista, Francisca Miriane Araújo
Santos, Jéssica Pereira Dos
Oliveira, Roselaine Sampaio
Nobre, Filipe Augusto de Freitas
Xavier, Samanta Cristina das Chagas
Carvalho-Costa, Filipe Anibal
Affilliation: Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil.
Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Piauí. Teresina, PI, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Abstract: Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a head circumference z-score between −2 and −3, 23 (25%) between −3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group.
Keywords: Microcephaly
Infants
Zika
State of Piauí
Issue Date: 2018
Citation: ALMEIDA, Isabel Marlúcia Lopes Moreira de et al. Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015–2016. Jornal de Pediatria, Rio de Janeiro, p. 1-9, 2018.
DOI: 10.1016/j.jped.2018.04.013
ISSN: 0021-7557
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
PI - Artigos de Periódicos

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