Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27401
Title: Potential overestimation of HIV-1 sub-subtype F1 circulation in Rio de Janeiro, Brazil
Authors: Marques, Bianca Cristina Leires
Morgado, Mariza Gonçalves
Guimarães, Monick Lindenmeyer
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract: In Brazil, detection of the HIV-1 sub-subtype F1 has decreased with a simultaneous increase in detection of the recombinant FB and FC forms. In previous HIV-1 env molecular epidemiology studies in Rio de Janeiro, 11.4% of the detected sequences were of the F1 sub-subtype. With the goal of re-estimating the prevalence of the HIV-1 F1 sub-subtype, we performed extended analyses of these samples by examining five genomic regions, resulting in 3.3% being confirmed as F1. Moreover, genomic analysis of 11 of the 21 samples identified as F1 confirmed that nine were F1 and two were BF1. Considering the number of samples assayed, the prevalence of F1 was quite low, which supports the use of different genomic regions for the assessment of HIV-1 classification in countries where several subtypes and recombinant forms co-circulate.
Keywords: HIV-1
sub-subtype F1
full-length genome
molecular epidemiology
genotyping
Brazil
keywords: HIV-1
Epidemiologia Molecular
Técnicas de Genotipagem
sub-subtipo F1
genoma completo
Rio de Janeiro
Issue Date: 2018
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: MARQUES, Bianca Cristina Leires; MORGADO, Mariza Gonçalves; GUIMARÂES, Monick Lindenmeyer. Potential overestimation of HIV-1 sub-subtype F1 circulation in Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz, v.113, n.8, e170483, 6p, 2018.
DOI: 10.1590/0074-02760170483
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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